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Kaposi sarcoma
Kaposi sarcoma (KS) gained public attention as an AIDS-defining malignancy; its
appearance on the skin was a highly stigmatizing sign of HIV infection during the height of …
appearance on the skin was a highly stigmatizing sign of HIV infection during the height of …
Pyroptotic cell death defends against intracellular pathogens
Inflammatory caspases play a central role in innate immunity by responding to cytosolic
signals and initiating a twofold response. First, caspase‐1 induces the activation and …
signals and initiating a twofold response. First, caspase‐1 induces the activation and …
Viral evasion of intracellular DNA and RNA sensing
The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …
Molecular mechanisms of viral oncogenesis in humans
NA Krump, J You - Nature Reviews Microbiology, 2018 - nature.com
Viral infection is a major contributor to the global cancer burden. Recent advances have
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …
The cGAS-STING defense pathway and its counteraction by viruses
Upon virus infection, host cells mount a concerted innate immune response involving type I
interferon and pro-inflammatory cytokines to enable elimination of the pathogen. Recently …
interferon and pro-inflammatory cytokines to enable elimination of the pathogen. Recently …
Human viral oncogenesis: a cancer hallmarks analysis
Approximately 12% of all human cancers are caused by oncoviruses. Human viral
oncogenesis is complex, and only a small percentage of the infected individuals develop …
oncogenesis is complex, and only a small percentage of the infected individuals develop …
Inflammasomes in health and disease
Inflammasomes are a group of protein complexes built around several proteins, including
NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and …
NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and …
HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production
Background & Aims Hepatitis B virus (HBV) has developed strategies to evade immune
responses. However, the mechanisms involved remain unclear. The NLRP3 inflammasome …
responses. However, the mechanisms involved remain unclear. The NLRP3 inflammasome …
Regulation of inflammasome signaling
Innate immune responses have the ability to both combat infectious microbes and drive
pathological inflammation. Inflammasome complexes are a central component of these …
pathological inflammation. Inflammasome complexes are a central component of these …
Inflammasomes and their roles in health and disease
Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …
activation of inflammatory caspases, which drive host and immune responses by releasing …