While critically ill patients experience a life-threatening illness, they commonly contract
ventilator-associated pneumonia. This nosocomial infection increases morbidity and likely …

These evidence-based guidelines have been produced after a systematic literature review
of a range of issues involving prevention, diagnosis and treatment of hospital-acquired …

Because of their extensive wounds, burn patients are chronically exposed to inflammatory
mediators. Thus, burn patients, by definition, already have “systemic inflammatory response …

Objectives Our primary goal was to evaluate the impact on in-hospital mortality rate of
adequate empirical antibiotic therapy, after controlling for confounding variables, in a cohort …

To compare efficacy and safety of a tigecycline regimen with an imipenem/cilastatin regimen
in hospital-acquired pneumonia patients, a phase 3, multicenter, randomized, double-blind …

Colonization of bacteria refers to the presence of bacteria without an active host response.
10 Bacterial colonization of the lungs can be due to spread of organisms from many different …

ABSTRACT A retrospective case series study was performed in a 30-bed general intensive
care unit (ICU) of a tertiary care hospital to assess the effectiveness and safety of colistin in …

Antimicrobial de-escalation (ADE) is defined as the discontinuation of one or more
components of combination empirical therapy, and/or the change from a broad-spectrum to …

Hospital acquired or nosocomial infections continue to be an important cause of morbidity
and mortality. The critically ill patient is at particular risk of develo** intensive care unit …

Objective To update the state-of-the-art on pneumonia in adult patients in the intensive care
unit (ICU), with special emphasis on new developments in management. Methods We …