Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Ion channels are vital contributors to cellular communication in a wide range of organisms, a
distinct feature that renders this ubiquitous family of membrane-spanning proteins a prime …

In spite of the recognition that striatal D2 receptors are critical determinants in a variety of
psychomotor disorders, the cellular mechanisms by which these receptors shape neuronal …

The Ca2+ channel α1A-subunit is a voltage-gated, pore-forming membrane protein
positioned at the intersection of two important lines of research: one exploring the diversity of …

Abstract L-type (Ca V 1.2) and P/Q-type (Ca V 2.1) calcium channels possess lobe-specific
CaM regulation, where Ca 2+ binding to one or the other lobe of CaM triggers regulation …

The computational power of the neocortex arises from interactions of multiple neurons,
which display a wide range of electrical properties. The gene expression profiles underlying …

Mutations in the CACNA1A gene that encodes the pore-forming α 1 subunit of human
voltage-gated Ca V 2.1 (P/Q-type) Ca 2+ channels cause several autosomal-dominant …

The postsynaptic effects of acetylcholine in the striatum are largely mediated by muscarinic
receptors. Two of the five cloned muscarinic receptors (M1 and M4) are expressed at high …

We describe a computational model of the principal cell in the nucleus accumbens (NAcb),
the medium spiny projection (MSP) neuron. The model neuron, constructed in NEURON …

A member of the neurotrophin family, brain-derived neurotrophic factor (BDNF) regulates
neuronal survival and differentiation during development. Within the adult brain, BDNF is …