The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most
Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even …

Monitoring of the cytosolic compartment by the innate immune system for pathogen-encoded
products or pathogen activities often enables the activation of a subset of caspases. In most …

Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Lipopolysaccharide (LPS), commonly known as endotoxin, is ubiquitous and the most-
studied pathogen-associated molecular pattern. A component of Gram-negative bacteria …

Canonical activation of the inflammasome is critical to promote caspase-1-dependent
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …

Inflammasomes are multi-component signaling complexes critical to the initiation of
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …

Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …