Blood biomarkers for stroke diagnosis and management

J Kamtchum-Tatuene, GC Jickling - Neuromolecular medicine, 2019 - Springer
Biomarkers are objective indicators used to assess normal or pathological processes,
evaluate responses to treatment and predict outcomes. Many blood biomarkers already …

Inflammation, autoimmunity, infection, and stroke: epidemiology and lessons from therapeutic intervention

NS Parikh, AE Merkler, C Iadecola - Stroke, 2020 - Am Heart Assoc
712 Stroke March 2020 outcome of stroke. 27, 28 Rosuvastatin reduced stroke risk in
subjects who either achieved LDL-C levels of< 70 mg/dL or hs-CRP levels of< 2 mg/L …

Colchicine in patients with acute ischaemic stroke or transient ischaemic attack (CHANCE-3): multicentre, double blind, randomised, placebo controlled trial

J Li, X Meng, FD Shi, J **g, HQ Gu, A **, Y Jiang, H Li… - bmj, 2024 - bmj.com
Objectives To assess the efficacy and safety of colchicine versus placebo on reducing the
risk of subsequent stroke after high risk non-cardioembolic ischaemic stroke or transient …

Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: analysis of 6 inflammation biomarkers in a prospective cohort study

J Li, J Lin, Y Pan, M Wang, X Meng, H Li… - Journal of …, 2022 - Springer
Objective Contribution of individual and combined inflammatory markers in prognosis after
stroke was still undefined. We aimed to investigate the association of systemic and local …

Atherosclerosis and multi-organ-associated pathologies

WC Keeter, S Ma, N Stahr, AK Moriarty… - Seminars in …, 2022 - Springer
Atherosclerosis is a chronic inflammatory disease of the vascular system that is
characterized by the deposition of modified lipoproteins, accumulation of immune cells, and …

C-Reactive Protein, Interleukin-6, and Vascular Recurrence According to Stroke Subtype: An Individual Participant Data Meta-Analysis

JJ McCabe, C Walsh, S Gorey, K Harris, P Hervella… - Neurology, 2024 - AAN Enterprises
Background and Objectives Anti-inflammatory therapies reduce major adverse
cardiovascular events (MACE) in coronary artery disease but remain unproven after stroke …

[HTML][HTML] Residual inflammatory risk predicts poor prognosis in acute ischemic stroke or transient ischemic attack patients

J Li, Y Pan, J Xu, S Li, M Wang, K Quan, X Meng, H Li… - Stroke, 2021 - journals.lww.com
Background and Purpose: It is still unclear whether the residual cholesterol and
inflammatory risk in the acute phase is associated with prognosis of stroke. We aimed to …

Mediation of systemic inflammation on insulin resistance and prognosis of nondiabetic patients with ischemic stroke

A **, S Wang, J Li, M Wang, J Lin, H Li, X Meng… - Stroke, 2023 - Am Heart Assoc
Background: Insulin resistance is associated with stroke recurrence and poor functional
outcomes of nondiabetic patients with ischemic stroke. The study aimed to investigate …

Interleukin-6, C-reactive protein, fibrinogen, and risk of recurrence after ischaemic stroke: systematic review and meta-analysis

JJ McCabe, E O'reilly, S Coveney… - European stroke …, 2021 - journals.sagepub.com
Background Recent randomised trials showed benefit for anti-inflammatory therapies in
coronary disease but excluded stroke. The prognostic value of blood inflammatory markers …

Anti-inflammatory approaches to ischaemic stroke prevention

PJ Kelly, S Murphy, S Coveney, F Purroy… - Journal of Neurology …, 2018 - jnnp.bmj.com
Stroke is a major cause of neurological morbidity and mortality. Atherosclerosis is a major
contributor to first and recurrent stroke. A growing evidence base indicates that inflammation …