Systematic Structure–Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments

CM St. Onge, PP Pagare, Y Zheng… - Journal of Medicinal …, 2024‏ - ACS Publications
Despite the availability of numerous pain medications, the current array of Food and Drug
Administration-approved options falls short in adequately addressing pain states for …

[HTML][HTML] Virtual display of targets: a new level to rise the current understanding of ochratoxin A toxicity from a molecular standpoint

F Perugino, L Pedroni, G Galaverna, C Dall'Asta… - Toxicology, 2024‏ - Elsevier
Ochratoxin A (OTA) is a mycotoxin spread worldwide contaminating several food and feed
commodities and rising concerns for humans and animals. OTA toxicity has been thoroughly …

Structure‐activity relationship and crystallographic studies on 4‐hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors

JP Holt‐Martyn, R Chowdhury, A Tumber… - …, 2020‏ - Wiley Online Library
The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are
targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is …

High intrinsic proton conduction in one three-dimensional indium (III)-organic framework built by amino terephthalic acid

YJ Song, P **ong, WM Shi, G Li - Journal of Solid State Chemistry, 2024‏ - Elsevier
It is imperative to carry out more research on the proton conduction in metal-organic
frameworks (MOFs) made of main group metals. Inspired by this, we synthesized a 3D …

Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5

MS Islam, M Markoulides, R Chowdhury… - Scientific Reports, 2022‏ - nature.com
Abstract JmjC (Jumonji-C) domain-containing 5 (JMJD5) plays important roles in circadian
regulation in plants and humans and is involved in embryonic development and cell …

Recent Advances and Therapeutic Implications of 2-Oxoglutarate-Dependent Dioxygenases in Ischemic Stroke

J **e, Z Zhang - Molecular Neurobiology, 2024‏ - Springer
Ischemic stroke is a common disease with a high disability rate and mortality, which brings
heavy pressure on families and medical insurance. Nowadays, the golden treatments for …

Electrochemical Conversion of N‐Sulfinylamines to Sulfonimidoyl Fluorides

FL Gao, X He, B Zhao, Y Lin… - Chinese Journal of …, 2024‏ - Wiley Online Library
Comprehensive Summary The invention of novel linkers is a long‐lasting task in the area of
the sulfur (VI) fluoride exchange reaction (SuFEx). Compared with the most frequently …

Design, synthesis and herbicidal activity of 5-acylbarbituric acid derivatives and study of molecular mode of action

K Lei, P Li, X Zhou, S Wang, X Wang, L Ji… - Chinese Journal of …, 2020‏ - sioc-journal.cn
有机化学 Page 1 有机化学 Chinese Journal of Organic Chemistry ARTICLE * Corresponding
author. E-mail: leikang@lcu.edu.cn Received May 13, 2020; revised June 15, 2020; published …

5-酰基巴比妥酸衍生物的设计, 合成及除草活性和分子作用机制研究

雷康, **攀, 周晓芸, 王世本, 王学堃, 冀卢莎, 柳仁民… - 有机化学, 2020‏ - sioc-journal.cn
有机化学 Page 1 有机化学 Chinese Journal of Organic Chemistry ARTICLE * Corresponding
author. E-mail: leikang@lcu.edu.cn Received May 13, 2020; revised June 15, 2020; published …

[PDF][PDF] МИНИСТЕРСТВО ОБРАЗОВАНИЯ И НАУКИ РОССИЙСКОЙ ФЕДЕРАЦИИ Федеральное государственное бюджетное образовательное учреждение …

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Мир, в котором мы живем, полон опасностей, постоянно угрожающих здоровью наших
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