Apical–basal polarity and the control of epithelial form and function
Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …
Structural features of tight-junction proteins
Tight junctions are complex supramolecular entities composed of integral membrane
proteins, membrane-associated and soluble cytoplasmic proteins engaging in an intricate …
proteins, membrane-associated and soluble cytoplasmic proteins engaging in an intricate …
The enigmatic function of PARP1: from PARylation activity to PAR readers
Poly (ADP-ribosyl) ation (PARylation) is catalysed by poly (ADP-ribose) polymerases
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …
Par complex cluster formation mediated by phase separation
Abstract The evolutionarily conserved Par3/Par6/aPKC complex regulates the polarity
establishment of diverse cell types and distinct polarity-driven functions. However, how the …
establishment of diverse cell types and distinct polarity-driven functions. However, how the …
PDZ domains as drug targets
NR Christensen, J Čalyševa… - Advanced …, 2019 - Wiley Online Library
Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …
often is promoted by specialized protein interaction modules, such as the postsynaptic …
[HTML][HTML] New insights into apical-basal polarization in epithelia
The establishment of an apical–basal axis of polarity is essential for the organization and
functioning of epithelial cells. Polarization of epithelial cells is orchestrated by a network of …
functioning of epithelial cells. Polarization of epithelial cells is orchestrated by a network of …
New insights into the organization and regulation of the apical polarity network in mammalian epithelial cells
Cell polarity is a fundamental property of most animal cells and is critical during
development and for most cell and tissue functions. Epithelial cells are organized into apical …
development and for most cell and tissue functions. Epithelial cells are organized into apical …
Juvenile hormone promotes paracellular transport of yolk proteins via remodeling zonula adherens at tricellular junctions in the follicular epithelium
Juvenile hormone (JH) acts as a gonadotrophic hormone stimulating insect vitellogenesis
and oogenesis. Paracellular transport of yolk proteins through intercellular channels …
and oogenesis. Paracellular transport of yolk proteins through intercellular channels …
Par‐3 family proteins in cell polarity & adhesion
BJ Thompson - The FEBS Journal, 2022 - Wiley Online Library
The Par‐3/Baz family of polarity determinants is highly conserved across metazoans and
includes C. elegans PAR‐3, Drosophila Bazooka (Baz), human Par‐3 (PARD3), and human …
includes C. elegans PAR‐3, Drosophila Bazooka (Baz), human Par‐3 (PARD3), and human …
Cdc42 defines apical identity and regulates epithelial morphogenesis by promoting apical recruitment of Par6-aPKC and Crumbs
Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-
aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work …
aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work …