Parkinson's disease (PD) is the most common neurodegenerative movement disorder,
worldwide. PD neuro-energetically affects the extrapyramidal system, by the progressive …

Abstract NLRP3 (NLRP3: NOD-, LRR-, and pyrin domain-containing protein 3)
inflammasome is the best-described inflammasome that plays a crucial role in the innate …

Abstracts Bowel inflammation, impaired intestinal epithelial barrier (IEB), and gut dysbiosis
could represent early events in Parkinson's disease (PD). This study examined, in a …

Abstract Microcystin-LR (MC-LR) has been confirmed to cause blood–brain barrier
disruption and enter the brain tissue, resulting in non-negligible toxic effects. However, the …

Parkinson's disease (PD) is characterized by progressive loss of dopaminergic neurons and
accumulation of misfolded alpha-synuclein (αSyn) into Lewy bodies. In addition to motor …

Parkinson's disease (PD) is closely related to iron accumulation and inflammation. Emerging
evidence indicates that TMEM106B plays an essential role in PD. But whether TMEM106B …

Despite significant advancements in the field of molecular neurobiology especially
neuroinflammation and neurodegeneration, the highly complex molecular mechanisms …

Parkinson's disease (PD) ranks as the second most prevalent neurodegenerative disorder,
and while the neuroprotective effects of estrogen are well-documented, the impact of …

Parkinson's disease (PD) and related synucleinopathies are characterized by chronic
neuroinflammation leading to the premise that anti-inflammatory therapies could ameliorate …

Abstract α-Synuclein (α-Syn) plays a key role in the development of Parkinson'desease
(PD). As aging is acknowledged to be the greatest risk factor for PD, here we investigated α …