In recent years, major advances have been made in the understanding of the cellular and
molecular mechanisms driving pulmonary vascular remodelling in various forms of …

Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their
flexible organization and functional redundancies make deciphering their sequence-function …

The heart, which is the first organ to develop, is highly dependent on its form to function,.
However, how diverse cardiac cell types spatially coordinate to create the complex …

Background A number of deep learning models have been developed to predict epigenetic
features such as chromatin accessibility from DNA sequence. Model evaluations commonly …

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

To identify cancer-associated gene regulatory changes, we generated single-cell chromatin
accessibility landscapes across eight tumor types as part of The Cancer Genome Atlas …

Summary lncRNA research is passing the stage of enumerating lncRNAs or recording
simplified on-off expression switches. Mechanistic analyses are starting to reveal …

Doxorubicin is limited in its therapeutic utility due to its life-threatening cardiovascular side
effects. Here, we present an integrated drug discovery pipeline combining human induced …

Cardiac pericytes (CPs), a major mural cell type maintaining homeostasis, integrity, and
perfusion of the coronary microvasculature, remain the most enigmatic and …

Illuminating the precise stepwise genetic programs directing cardiac development provides
insights into the mechanisms of congenital heart disease and strategies for cardiac …