Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the
loss or failure of an organ or tissue, with the aim to restore the dysfunctional tissues and …

Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …

Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation.
However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically …

There is growing appreciation of the role that the extracellular environment plays in
regulating cell behavior. Mechanical, structural, and compositional cues, either alone or in …

Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Two-dimensional and three-dimensional cell culture systems are widely used for biological
studies, and are the basis of the organoid, tissue engineering and organ-on-chip research …

Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Hydrogels are a class of polymer materials with three-dimensional networks structure, which
can absorb a large number of water and biological fluids. Natural polysaccharides are ideal …

Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …