Shear stress is essential for normal physiology and malignancy. Common physiological
processes–such as blood flow, particle flow in the gut, or contact between migratory cell …

Spatially resolved transcriptomics (SRT) has unlocked new dimensions in our
understanding of intricate tissue architectures. However, this rapidly expanding field …

Single-cell and spatial transcriptome sequencing, two recently optimized transcriptome
sequencing methods, are increasingly used to study cancer and related diseases. Cell …

Conventional tumor models have critical shortcomings in that they lack the complexity of the
human stroma. The heterogeneous stroma is a central compartment of the tumor …

Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor
occurrence and development for its ability to study gene expression at the individual cell …

The proper functioning of diverse biological systems depends on the spatial organization of
their cells, a critical factor for biological processes like sha** intricate tissue functions and …

Background: Cancer-associated fibroblasts (CAFs) are the key components of the immune
barrier in liver cancer. Therefore, gaining a deeper understanding of the heterogeneity and …

Spatial transcriptomics is revolutionizing the exploration of intratissue heterogeneity in
cancer, yet capturing cellular niches and their spatial relationships remains challenging. We …

Stromal cells are physiologically essential components of the tumor microenvironment
(TME) that mediates tumor development and therapeutic resistance. Development of a …

Solid tumours exhibit a well‐defined architecture, comprising a differentiated core and a
dynamic border that interfaces with the surrounding tissue. This border, characterised by …