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Interferon-gamma (IFN-γ): Exploring its implications in infectious diseases
A key player in driving cellular immunity, IFN-γ is capable of orchestrating numerous
protective functions to heighten immune responses in infections and cancers. It can exhibit …
protective functions to heighten immune responses in infections and cancers. It can exhibit …
Immunology of Mycobacterium tuberculosis Infections
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …
The mycobacterial cell envelope—a moving target
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …
CRISPR screens for functional interrogation of immunity
CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …
offer a powerful platform for unbiased screening and functional genomics in various fields …
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …
leading cause of death from an infectious disease, with a mortality rate of over a million …
Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), a leading
infectious disease of humans worldwide. One of the main histopathological hallmarks of TB …
infectious disease of humans worldwide. One of the main histopathological hallmarks of TB …
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization
Lung granulomas are the pathologic hallmark of tuberculosis (TB). T cells are a major
cellular component of TB lung granulomas and are known to play an important role in …
cellular component of TB lung granulomas and are known to play an important role in …
Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis
Z Hmama, S Peña‐Díaz, S Joseph… - Immunological …, 2015 - Wiley Online Library
By virtue of their position at the crossroads between the innate and adaptive immune
response, macrophages play an essential role in the control of bacterial infections …
response, macrophages play an essential role in the control of bacterial infections …
Extracellular vesicles and infectious diseases: new complexity to an old story
Exosomes and other extracellular microvesicles (ExMVs) have important functions in
intercellular communication and regulation. During the course of infection, these vesicles …
intercellular communication and regulation. During the course of infection, these vesicles …
Tuberculosis pathogenesis and immunity
Despite the development of potentially curative chemotherapy, tuberculosis (TB) continues
to cause increasing worldwide morbidity and is a leading cause of human mortality in the …
to cause increasing worldwide morbidity and is a leading cause of human mortality in the …