DNA end resection: mechanism and control
P Cejka, LS Symington - Annual review of genetics, 2021 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
DNA damage: from threat to treatment
A Carusillo, C Mussolino - Cells, 2020 - mdpi.com
DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
[HTML][HTML] The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism
T Kambe, T Tsuji, A Hashimoto… - Physiological …, 2015 - journals.physiology.org
Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …
Mechanism and regulation of DNA end resection in eukaryotes
LS Symington - Critical reviews in biochemistry and molecular …, 2016 - Taylor & Francis
The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
Structural basis and regulation of the reductive stress response
AG Manford, EL Mena, KY Shih, CL Gee, R McMinimy… - Cell, 2021 - cell.com
Although oxidative phosphorylation is best known for producing ATP, it also yields reactive
oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological …
oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological …
Double-strand break end resection and repair pathway choice
LS Symington, J Gautier - Annual review of genetics, 2011 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …
[HTML][HTML] Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions
M Rotheneder, K Stakyte, E van de Logt, JD Bartho… - Molecular cell, 2023 - cell.com
The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …
Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
The MRE11 complex: starting from the ends
The maintenance of genome stability depends on the DNA damage response (DDR), which
is a functional network comprising signal transduction, cell cycle regulation and DNA repair …
is a functional network comprising signal transduction, cell cycle regulation and DNA repair …