Charge transfer through the DNA base stack

RE Holmlin, PJ Dandliker… - … International Edition in …, 1997 - Wiley Online Library
Whether the DNA base pair stack might serve as a medium for efficient, long‐range charge
transfer has been debated almost since the first proposal of the double‐helical structure of …

Extending nature's leads: the anticancer agent ellipticine

NC Garbett, DE Graves - Current Medicinal Chemistry-Anti …, 2004 - ingentaconnect.com
The natural plant product ellipticine was isolated in 1959 from the Australian evergreen tree
of the Apocynaceae family. This compound was found to be an extremely promising …

Oxidative DNA damage through long-range electron transfer

DB Hall, RE Holmlin, JK Barton - Nature, 1996 - nature.com
THE possibility has been considered for almost forty years that the DNA double helix, which
contains a π-stacked array of heterocyclic base pairs, could be a suitable medium for the …

Electrochemistry of methylene blue bound to a DNA-modified electrode

SO Kelley, JK Barton, NM Jackson… - Bioconjugate …, 1997 - ACS Publications
Gold surfaces have been derivatized with 15-base-pair double-stranded DNA
oligonucleotides containing a pendant 5 'hexanethiol linker. The electrochemistry of …

Simultaneous activation of immunogenic cell death and cGAS-STING pathway by liver-and mitochondria-targeted gold (I) complexes for chemoimmunotherapy of …

F Li, Z Wen, C Wu, Z Yang, Z Wang… - Journal of Medicinal …, 2024 - ACS Publications
Induction of immunogenic cell death (ICD) and activation of the cyclic GMP-AMP synthase
stimulator of interferon gene (cGAS-STING) pathway are two potent anticancer …

Metal based pharmacologically active agents: Synthesis, structural characterization, molecular modeling, CT-DNA binding studies and in vitro antimicrobial screening …

LH Abdel-Rahman, RM El-Khatib, LAE Nassr… - … Acta Part A: Molecular …, 2014 - Elsevier
In recent years, great interest has been focused on Fe (II) Schiff base amino acid complexes
as cytotoxic and antitumor drugs. Thus a series of new iron (II) complexes based on Schiff …

DNA-binding and cleavage studies of macrocyclic copper (II) complexes

J Liu, T Zhang, T Lu, L Qu, H Zhou, Q Zhang… - Journal of inorganic …, 2002 - Elsevier
Three hexaaza macrocyclic copper (II) complexes with different functional groups have been
synthesized and characterized by elemental analysis and infrared spectra. Absorption and …

Long-range oxidative damage to DNA: effects of distance and sequence

ME Núñez, DB Hall, JK Barton - Chemistry & biology, 1999 - cell.com
Introduction Oxidative damage to DNA in vivo can lead to mutations and cancer. DNA
damage and repair studies have not yet revealed whether permanent oxidative lesions are …

New ruthenium (II) arene complexes of anthracenyl-appended diazacycloalkanes: effect of ligand intercalation and hydrophobicity on DNA and protein binding and …

M Ganeshpandian, R Loganathan, E Suresh… - Dalton …, 2014 - pubs.rsc.org
A series of half-sandwich Ru (II) arene complexes of the type [Ru (η6-arene)(L) Cl](PF6) 1–
4, where arene is benzene (1, 2) or p-cymene (3, 4) and L is N-methylhomopiperazine (L1) …

Study on potential antitumor mechanism of a novel Schiff Base copper (II) complex: synthesis, crystal structure, DNA binding, cytotoxicity and apoptosis induction …

X Qiao, ZY Ma, CZ **e, F Xue, YW Zhang, JY Xu… - Journal of inorganic …, 2011 - Elsevier
A new cytotoxic copper (II) complex with Schiff base ligand [Cu II (5-Cl-pap)(OAc)(H 2 O)]·
2H 2 O (1)(5-Cl-pap= N-2-pyridiylmethylidene-2-hydroxy-5-chloro-phenylamine), was …