Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology
Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier function
is critical for the maintenance of physiological processes and extremely sensitive to …
is critical for the maintenance of physiological processes and extremely sensitive to …
Computational tools for cellular scale biophysics
Mathematical models are indispensable for disentangling the interactions through which
biological components work together to generate the forces and flows that position, mix, and …
biological components work together to generate the forces and flows that position, mix, and …
Topological packing statistics of living and nonliving matter
Complex disordered matter is of central importance to a wide range of disciplines, from
bacterial colonies and embryonic tissues in biology to foams and granular media in …
bacterial colonies and embryonic tissues in biology to foams and granular media in …
Mechanics and morphology of proliferating cell collectives with self-inhibiting growth
We study the dynamics of proliferating cell collectives whose microscopic constituents'
growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a …
growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a …
[HTML][HTML] A numerical solver for active hydrodynamics in three dimensions and its application to active turbulence
We present a higher-order convergent numerical solver for active polar hydrodynamics in
three-dimensional domains of arbitrary shape, along with a scalable open-source software …
three-dimensional domains of arbitrary shape, along with a scalable open-source software …
Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly
MH Jones, ZR Gergely, D Steckhahn, B Zhou… - Current Biology, 2024 - cell.com
Kinesin-5 motors play an essential role during mitotic spindle assembly in many organisms
1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11: they crosslink antiparallel spindle microtubules, step toward …
1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11: they crosslink antiparallel spindle microtubules, step toward …
Discrete network models of endothelial cells and their interactions with the substrate
Endothelial cell monolayers line the inner surfaces of blood and lymphatic vessels. They are
continuously exposed to different mechanical loads, which may trigger mechanobiological …
continuously exposed to different mechanical loads, which may trigger mechanobiological …
Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors
Microtubules and molecular motors are essential components of the cellular cytoskeleton,
driving fundamental processes in vivo, including chromosome segregation and cargo …
driving fundamental processes in vivo, including chromosome segregation and cargo …
[HTML][HTML] Accurate close interactions of Stokes spheres using lubrication-adapted image systems
Stokes flows with near-touching rigid particles induce near-singular lubrication forces under
relative motion, making their accurate numerical treatment challenging. With the aim of …
relative motion, making their accurate numerical treatment challenging. With the aim of …
Slender body theories for rotating filaments
Slender fibres are ubiquitous in biology, physics and engineering, with prominent examples
including bacterial flagella and cytoskeletal fibres. In this setting, slender body theories …
including bacterial flagella and cytoskeletal fibres. In this setting, slender body theories …