Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology

P Keshavanarayana, R Aparicio-Yuste, F Spill… - Trends in Cell …, 2025 - cell.com
Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier function
is critical for the maintenance of physiological processes and extremely sensitive to …

Computational tools for cellular scale biophysics

DB Stein, MJ Shelley - Current Opinion in Cell Biology, 2024 - Elsevier
Mathematical models are indispensable for disentangling the interactions through which
biological components work together to generate the forces and flows that position, mix, and …

Topological packing statistics of living and nonliving matter

DJ Skinner, H Jeckel, AC Martin, K Drescher… - Science …, 2023 - science.org
Complex disordered matter is of central importance to a wide range of disciplines, from
bacterial colonies and embryonic tissues in biology to foams and granular media in …

Mechanics and morphology of proliferating cell collectives with self-inhibiting growth

S Weady, B Palmer, A Lamson, T Kim, R Farhadifar… - Physical Review Letters, 2024 - APS
We study the dynamics of proliferating cell collectives whose microscopic constituents'
growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a …

[HTML][HTML] A numerical solver for active hydrodynamics in three dimensions and its application to active turbulence

A Singh, PH Suhrcke, P Incardona, IF Sbalzarini - Physics of Fluids, 2023 - pubs.aip.org
We present a higher-order convergent numerical solver for active polar hydrodynamics in
three-dimensional domains of arbitrary shape, along with a scalable open-source software …

Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly

MH Jones, ZR Gergely, D Steckhahn, B Zhou… - Current Biology, 2024 - cell.com
Kinesin-5 motors play an essential role during mitotic spindle assembly in many organisms
1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11: they crosslink antiparallel spindle microtubules, step toward …

Discrete network models of endothelial cells and their interactions with the substrate

R Jakob, BR Britt, C Giampietro, E Mazza… - … and Modeling in …, 2024 - Springer
Endothelial cell monolayers line the inner surfaces of blood and lymphatic vessels. They are
continuously exposed to different mechanical loads, which may trigger mechanobiological …

Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors

B Najma, WS Wei, A Baskaran… - Proceedings of the …, 2024 - National Acad Sciences
Microtubules and molecular motors are essential components of the cellular cytoskeleton,
driving fundamental processes in vivo, including chromosome segregation and cargo …

[HTML][HTML] Accurate close interactions of Stokes spheres using lubrication-adapted image systems

A Broms, AH Barnett, AK Tornberg - Journal of Computational Physics, 2025 - Elsevier
Stokes flows with near-touching rigid particles induce near-singular lubrication forces under
relative motion, making their accurate numerical treatment challenging. With the aim of …

Slender body theories for rotating filaments

O Maxian, A Donev - Journal of Fluid Mechanics, 2022 - cambridge.org
Slender fibres are ubiquitous in biology, physics and engineering, with prominent examples
including bacterial flagella and cytoskeletal fibres. In this setting, slender body theories …