Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting
upper and lower motor neurons. The disease leads to relentlessly progressive weakness of …

Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

The Endoplasmic Reticulum (ER) is an endomembrane system that plays a multiplicity of
roles in cell physiology and populates even the most distal cell compartments, including …

Disruptions to genes linked to RNA processing and homeostasis are implicated in the
pathogenesis of two pathologically related but clinically heterogeneous neurodegenerative …

How do C9ORF72 repeat expansions cause amyotrophic lateral s... : Current Opinion in
Neurology How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that results
in loss of the upper and lower motor neurons from motor cortex, brainstem, and spinal cord …

Amyotrophic lateral sclerosis (ALS) is a fatal late onset neurological disorder characterized
by motor neuron degeneration in the primary motor cortex, brainstem and spinal cord. The …

Amyotrophic lateral sclerosis (ALS) is a terminal disease involving the progressive
degeneration of motor neurons within the motor cortex, brainstem and spinal cord. Most …