A high intratumoral nerve density is correlated with poor survival, high metastasis, and high
recurrence across multiple solid tumor types. Recent research has revealed that cancer cells …

Perineural invasion (PNI) is the process through which tumors invade and interact with
nerves. The dynamic changes in the nerves caused by PNI may induce disturbing …

Cancer still represents a major global burden, being the second leading cause of death
worldwide [1]. Standard cancer treatments include surgery, radiotherapy and chemotherapy …

Simple Summary The contribution of neuronal innervation to cancer development and
persistence is not well understood. In the current study, a novel microsurgical technique for …

The importance of neurons and nerve fibers in the tumor microenvironment (TME) of solid
tumors is now acknowledged after being unexplored for a long time; this is possible due to …

The role of the nervous system in aiding cancer progression and metastasis is an important
aspect of cancer pathogenesis. Interaction between cancer cells and neurons in an in vitro …

Background Tumor innervation has been shown to be utilized by some solid cancers to
support tumor initiation, growth, progression, and metastasis, as well as confer resistance to …

We propose an overview of the molecular cues and their intracellular signaling involved in
the crosstalk between cancer and the nervous system. While “cancer neuroscience” as a …

It is considered that sensory neurons extend into the tumor microenvironment (TME), which
could be associated with tumor growth. However, little is known about how sensory …

In recent decades, the mortality and morbidity of Gastrointestinal (GI) cancer have
remarkably increased, especially in younger individuals. Recent studies revealed that …