Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Bioactive synthetic polymers

K Jung, N Corrigan, EHH Wong, C Boyer - Advanced Materials, 2022 - Wiley Online Library
Synthetic polymers are omnipresent in society as textiles and packaging materials, in
construction and medicine, among many other important applications. Alternatively, natural …

SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2

TM Clausen, DR Sandoval, CB Spliid, J Pihl… - Cell, 2020 - cell.com
We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and
angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD) …

SARS-CoV-2 and the host cell: a tale of interactions

M Pizzato, C Baraldi, G Boscato Sopetto… - Frontiers in …, 2022 - frontiersin.org
The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …

The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection

L Henss, A Auste, C Schürmann… - Journal of General …, 2021 - microbiologyresearch.org
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has caused a
pandemic with tens of millions of cases and more than a million deaths. The infection causes …

Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

SJL Petitjean, W Chen, M Koehler, R Jimmidi… - Nature …, 2022 - nature.com
The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent
need to better understand the molecular details of the virus binding to its host cell and to …

Single-molecule imaging reveals allosteric stimulation of SARS-CoV-2 spike receptor binding domain by host sialic acid

MA Díaz-Salinas, A Jain, ND Durham, JB Munro - Science Advances, 2024 - science.org
Conformational dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) spike glycoprotein (S) mediate exposure of the binding site for the cellular receptor …

Glycans of SARS-CoV-2 spike protein in virus infection and antibody production

X Zhao, H Chen, H Wang - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Viral protein glycosylation represents a successful strategy employed by the parasite to take
advantage of host–cell machinery for modification of its own proteins. The resulting glycans …

Single-molecule force stability of the SARS-CoV-2–ACE2 interface in variants-of-concern

MS Bauer, S Gruber, A Hausch, MCR Melo… - Nature …, 2024 - nature.com
Mutations in SARS-CoV-2 have shown effective evasion of population immunity and
increased affinity to the cellular receptor angiotensin-converting enzyme 2 (ACE2) …

Influence of host sialic acid receptors structure on the host specificity of influenza viruses

C Zhao, J Pu - Viruses, 2022 - mdpi.com
Influenza viruses need to use sialic acid receptors to invade host cells, and the α-2, 3 and α-
2, 6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to …