Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular
disease. As a multifactorial and systemic disease that involves multiple organs and systems …

Almost 200 years ago, the first evidence described by Robert Bright (1836) showed the
strong interaction between the kidneys and heart and, since then, the scientific community …

Hypertension is a highly prevalent chronic disease and the major risk factor for
cardiovascular diseases, the leading cause of death worldwide. Hypertension is …

It has been 45 years since Gunther Schlager used a cross breeding program in mice to
develop inbred strains with high, normal, and low blood pressure (BPH/2, BPN/3, and BPL/1 …

Increasing studies strongly prove that renal denervation, a minimally invasive surgery, is a
promising new non-drug treatment method that can effectively control blood pressure in …

Animal models that recapitulate human diseases and disorders are widely used to
investigate etiology, diagnosis, and treatment of those conditions in people. Disorders …

Renal denervation (RDNX) lowers mean arterial pressure (MAP) in patients with resistant
hypertension. Less well studied is the effect of celiac ganglionectomy (CGX), a procedure …

BPH/2J mice are a genetic model of hypertension with overactivity of the sympathetic
nervous system (SNS) and renin–angiotensin system (RAS). BPH/2J display higher renal …

Background and Purpose All previous rodent models lacking the peptide hormone
angiotensin II (Ang II) were hypotensive. A mixed background strain with global deletion of …

We examined the effect of total and afferent renal denervation (RDN) on hypertension and
the renin-angiotensin system (RAS) in a rodent model of juvenile-onset polycystic kidney …