Glutamatergic transmission is widely implicated in neuropsychiatric disorders, and the
discovery that ketamine elicits rapid-acting antidepressant effects by modulating α-amino-3 …

Aminothiophenes are important five-membered heterocyclic building blocks in organic
synthesis, and the chemistry of these small molecules is still develo** based on the …

1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …

L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS).
Its associated receptors localized on neuronal and non-neuronal cells mediate rapid …

Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …

Highlights•Better AMPAR positive allosteric modulators are being developed.•New
methodologies and approaches enhance the analysis of their activity in vitro.•AMPA positive …

Mental disorders are neuropsychiatric conditions that are marked by unusual or irregular
thinking, feelings, or behavior, and lead to distress and/or impaired functions. Major …

This paper summarizes the present knowledge on how positive allosteric modulators
(PAMs) interact with the ligand‐binding domain (LBD) of AMPA and kainate receptors …

Ionotropic glutamate receptors (iGluRs) are ligand gated ion channels that mediate
excitatory synaptic transmission in the brain of vertebrates. A rapidly growing body of crystal …

Straightforward practical synthetic approaches to 3, 4-bis-and 3, 4, 5-tris (trifluoromethyl)
pyrazoles have been developed. The key step of the both syntheses is a transformation of …