DNA synthesis technologies to close the gene writing gap

A Hoose, R Vellacott, M Storch, PS Freemont… - Nature Reviews …, 2023 - nature.com
Synthetic DNA is of increasing demand across many sectors of research and commercial
activities. Engineering biology, therapy, data storage and nanotechnology are set for rapid …

Hydrogels as functional components in artificial cell systems

ME Allen, JW Hindley, DK Baxani, O Ces… - Nature Reviews …, 2022 - nature.com
Recent years have seen substantial efforts aimed at constructing artificial cells from various
molecular components with the aim of mimicking the processes, behaviours and …

Molecular dynamics simulation of an entire cell

JA Stevens, F Grünewald, PAM van Tilburg… - Frontiers in …, 2023 - frontiersin.org
The ultimate microscope, directed at a cell, would reveal the dynamics of all the cell's
components with atomic resolution. In contrast to their real-world counterparts …

Cell-free gene expression

D Garenne, MC Haines, EF Romantseva… - Nature reviews …, 2021 - nature.com
Cell-free gene expression (CFE) emerged as an alternative approach to living cells for
specific applications in protein synthesis and labelling for structural biology and proteomics …

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

T Thi Nhu Thao, F Labroussaa, N Ebert, P V'kovski… - Nature, 2020 - nature.com
Reverse genetics has been an indispensable tool to gain insights into viral pathogenesis
and vaccine development. The genomes of large RNA viruses, such as those from …

Total synthesis of Escherichia coli with a recoded genome

J Fredens, K Wang, D De La Torre, LFH Funke… - Nature, 2019 - nature.com
Nature uses 64 codons to encode the synthesis of proteins from the genome, and chooses 1
sense codon—out of up to 6 synonyms—to encode each amino acid. Synonymous codon …

Emerging technologies in algal biotechnology: toward the establishment of a sustainable, algae-based bioeconomy

M Fabris, RM Abbriano, M Pernice… - Frontiers in plant …, 2020 - frontiersin.org
Mankind has recognized the value of land plants as renewable sources of food, medicine,
and materials for millennia. Throughout human history, agricultural methods were …

The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology

TE Sandberg, MJ Salazar, LL Weng, BO Palsson… - Metabolic …, 2019 - Elsevier
Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …

Chemically and biologically engineered bacteria‐based delivery systems for emerging diagnosis and advanced therapy

Z Li, Y Wang, J Liu, P Rawding, J Bu… - Advanced …, 2021 - Wiley Online Library
Bacteria are one of the main groups of organisms, which dynamically and closely participate
in human health and disease development. With the integration of chemical biotechnology …

Tumour-targeting bacteria engineered to fight cancer

S Zhou, C Gravekamp, D Bermudes, K Liu - Nature Reviews Cancer, 2018 - nature.com
Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …