Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …

Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

Background Epilepsy is a common and debilitating consequence of traumatic brain injury
(TBI). Seizures contribute to progressive neurodegeneration and poor functional and …

Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

The brain is composed of many lipids with varied forms that serve not only as structural
components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an …

Deregulated lipid metabolism may be of particular importance for CNS injuries and
disorders, as this organ has the highest lipid concentration next to adipose tissue …

Brain insults, including traumatic and ischemic injuries, are frequently followed by acute
seizures and delayed development of epilepsy. Dysfunction of the blood‐brain barrier (BBB) …

Epileptogenesis is common following brain insults such as trauma, ischemia and infection.
However, the mechanisms underlying injury-related epileptogenesis remain unknown …

An increasing body of evidence suggested that intracellular lipid metabolism is dramatically
perturbed in various cardiovascular and neurodegenerative diseases with genetic and …

Lysophosphatidic acid (LPA) is a bioactive phospholipid controlling numerous cellular
responses through the activation of specific G-protein coupled transmembrane receptors …