Preparing for the next viral threat with broad-spectrum antivirals

M Karim, CW Lo, S Einav - The Journal of clinical investigation, 2023 - jci.org
There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …

The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs

Y Li, S Huo, Z Yin, Z Tian, F Huang, P Liu, Y Liu, F Yu - Mbio, 2023 - journals.asm.org
Influenza viruses (IVs) threaten global human health due to the high morbidity, infection, and
mortality rates. Currently, the influenza drugs recommended by the FDA are oseltamivir …

Favipiravir versus arbidol for COVID-19: a randomized clinical trial

C Chen, J Huang, P Yin, Y Zhang, Z Cheng, J Wu… - MedRxiv, 2020 - medrxiv.org
Importance WHO has made the assessment that coronavirus disease 2019 (COVID-19) can
be characterized as a pandemic. So far, there is no clinically proven effective antiviral drug …

Favipiravir versus arbidol for clinical recovery rate in moderate and severe adult COVID-19 patients: a prospective, multicenter, open-label, randomized controlled …

C Chen, Y Zhang, J Huang, P Yin, Z Cheng… - Frontiers in …, 2021 - frontiersin.org
Background: In addition to supportive therapy, antiviral therapy is an effective treatment for
coronavirus disease 2019 (COVID-19). Objective: To compare the efficacy and safety of …

The impact of the COVID-19 “Infodemic” on drug-utilization behaviors: implications for pharmacovigilance

M Tuccori, I Convertino, S Ferraro, E Cappello… - Drug safety, 2020 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic that hit the world in 2020
triggered a massive dissemination of information (an “infodemic”) about the disease that was …

Molecular investigation of SARS–CoV-2 proteins and their interactions with antiviral drugs

P Calligari, S Bobone, G Ricci, A Bocedi - Viruses, 2020 - mdpi.com
A new Coronavirus strain, named SARS-CoV-2, suddenly emerged in early December
2019. SARS-CoV-2 resulted in being dramatically infectious, with thousands of people …

Unraveling the mechanism of arbidol binding and inhibition of SARS-CoV-2: Insights from atomistic simulations

AK Padhi, A Seal, JM Khan, M Ahamed… - European journal of …, 2021 - Elsevier
The COVID-19 pandemic has spread rapidly and poses an unprecedented threat to the
global economy and human health. Broad-spectrum antivirals are currently being …

Retracted and republished from:“The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs”

Y Li, S Huo, Z Yin, Z Tian, F Huang, P Liu, Y Liu, F Yu - Mbio, 2024 - journals.asm.org
Influenza viruses (IVs) threaten global human health due to the high morbidity, infection, and
mortality rates. Currently, the influenza drugs recommended by the Food and Drug …

Data-driven molecular design for discovery and synthesis of novel ligands: a case study on SARS-CoV-2

J Born, M Manica, J Cadow, G Markert… - Machine Learning …, 2021 - iopscience.iop.org
Bridging systems biology and drug design, we propose a deep learning framework for de
novo discovery of molecules tailored to bind with given protein targets. Our methodology is …

Antioxidant potential of antiviral drug umifenovir

EV Proskurnina, DY Izmailov, MM Sozarukova… - Molecules, 2020 - mdpi.com
Free radical reactions play an important role in biological functions of living systems. The
balance between oxidants and antioxidants is necessary for the normal homeostasis of cells …