Coronavirus vaccine development: from SARS and MERS to COVID-19

YD Li, WY Chi, JH Su, L Ferrall, CF Hung… - Journal of biomedical …, 2020 - Springer
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of
coronavirus that causes the Coronavirus Disease 2019 (COVID-19), which has been the …

Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children

P Zimmermann, N Curtis - The Pediatric infectious disease journal, 2020 - journals.lww.com
Coronaviruses (CoVs) are a large family of enveloped, single-stranded, zoonotic RNA
viruses. Four CoVs commonly circulate among humans: HCoV2-229E,-HKU1,-NL63 and …

Broadly neutralizing antibodies target the coronavirus fusion peptide

C Dacon, C Tucker, L Peng, CCD Lee, TH Lin, M Yuan… - Science, 2022 - science.org
The potential for future coronavirus outbreaks highlights the need to broadly target this
group of pathogens. We used an epitope-agnostic approach to identify six monoclonal …

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

KS Corbett, DK Edwards, SR Leist, OM Abiona… - Nature, 2020 - nature.com
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to
control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have …

[HTML][HTML] Structural and functional basis of SARS-CoV-2 entry by using human ACE2

Q Wang, Y Zhang, L Wu, S Niu, C Song, Z Zhang, G Lu… - Cell, 2020 - cell.com
The recent emergence of a novel coronavirus (SARS-CoV-2) in China has caused
significant public health concerns. Recently, ACE2 was reported as an entry receptor for …

[HTML][HTML] Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

CO Barnes, AP West, KE Huey-Tubman… - Cell, 2020 - cell.com
Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain
(RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) …

mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants

K Wu, AP Werner, JI Moliva, M Koch, A Choi… - BioRxiv, 2021 - biorxiv.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative infection of
a global pandemic that has led to more than 2 million deaths worldwide. The Moderna …

[HTML][HTML] Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies

D Wrapp, D De Vlieger, KS Corbett, GM Torres… - Cell, 2020 - cell.com
Coronaviruses make use of a large envelope protein called spike (S) to engage host cell
receptors and catalyze membrane fusion. Because of the vital role that these S proteins play …

The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens

L Duan, Q Zheng, H Zhang, Y Niu, Y Lou… - Frontiers in …, 2020 - frontiersin.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …

[PDF][PDF] Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19)

B Shanmugaraj, K Siriwattananon… - Asian Pacific journal …, 2020 - apjai-journal.org
Last decade witnessed the outbreak of many life-threatening human pathogens including
Nipah, Ebola, Chikungunya, Zika, Middle East respiratory syndrome coronavirus (MERS …