Publisher Summary This chapter focuses on structure and expression of interleukin-6 (IL-6),
which is a cytokine with pleiotropic activities that plays a central role in host defense. IL-6 …

Inflammation leads to changes in lipid metabolism aimed at decreasing the toxicity of a
variety of harmful agents and tissue repair by redistributing nutrients to cells involved in host …

Cytokines are usually extracellular signalling proteins, usually less than 80 kD in size, and
many are glycosylated. They are produced by many diVerent cell types that are involved in …

Pleiotropy and Redundancy Communication between cells in immune and hematopoietic
systems is mediated by soluble factors called interleukins or cytokines. These molecules …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

We reported that interleukin (IL) 6 alone cannot induce osteoclast formation in cocultures of
mouse bone marrow and osteoblastic cells, but soluble IL-6 receptor (IL-6R) strikingly …

F weights of recombinant human (rh) and murine IL-11 are 19,144 daltons6 and 19,154
daltons, 2 respectively. Mature IRST ISOLATED IN 1990, interleukin-11 (IL-11) has proven to …

Endotoxin, via cytokines, induces marked changes in lipid metabolism: serum VLDL
increases, whereas the effect on LDL levels varies among species. The increase in VLDL is …

Abstract The interleukin 6 (IL-6) cytokine family, which includes IL-6, leukemia inhibitory
factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), IL-11 and cardiotrophin …

An adult mouse liver cDNA library was screened with oligonucleotides corresponding to the
conserved WSXWS motif of the haemopoietin receptor family. Using this method, cDNA …