New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine map**, gene prioritization and causal inference
X Meng, G Navoly, O Giannakopoulou, DF Levey… - Nature …, 2024 - nature.com
Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
Cardiovascular disease and depression: A narrative review
X Li, J Zhou, M Wang, C Yang, G Sun - Frontiers in Cardiovascular …, 2023 - frontiersin.org
In clinical practice, it is frequently observed that cardiac and psychological disorders
frequently co-occur, leading to the emergence of a field known as cardiovascular disease …
frequently co-occur, leading to the emergence of a field known as cardiovascular disease …
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …
Investigating the shared genetic architecture between depression and subcortical volumes
M Liu, L Wang, Y Zhang, H Dong, C Wang… - Nature …, 2024 - nature.com
Depression, a widespread and highly heritable mental health condition, profoundly affects
millions of individuals worldwide. Neuroimaging studies have consistently revealed …
millions of individuals worldwide. Neuroimaging studies have consistently revealed …
A potential role for MAGI-1 in the bi-directional relationship between Major Depressive Disorder and Cardiovascular Disease
Abstract Purpose of Review Major Depressive Disorder (MDD) is characterized by persistent
symptoms such as fatigue, loss of interest in activities, feelings of sadness and …
symptoms such as fatigue, loss of interest in activities, feelings of sadness and …
[PDF][PDF] Bidirectional Mendelian randomization and multiphenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes
OBJECTIVE Depression is a common comorbidity of type 2 diabetes. We assessed the
causal relationships and shared genetics between them. RESEARCH DESIGN AND …
causal relationships and shared genetics between them. RESEARCH DESIGN AND …
The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and risk of depression among US adults: a …
X Qi, S Wang, Q Huang, X Chen, L Qiu… - Journal of Affective …, 2024 - Elsevier
Background NHHR (non-high-density lipoprotein cholesterol to high-density lipoprotein
cholesterol ratio) is a new lipid parameter used to assess the risk of cardiovascular disease …
cholesterol ratio) is a new lipid parameter used to assess the risk of cardiovascular disease …
Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease
Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid,
resulting in excess morbidity and mortality. Here we show that CVDs share most of their …
resulting in excess morbidity and mortality. Here we show that CVDs share most of their …
A Pilot Interaction Analysis of Gut Microbiota and Peripheral Markers of Aging in Severe Psychiatric Disorders: A Role for Lachnoclostridium?
M Manchia, P Paribello, C Pisanu, D Congiu… - International Journal of …, 2023 - mdpi.com
Excessive predominance of pathological species in the gut microbiota could increase the
production of inflammatory mediators at the gut level and, via modification of the gut–blood …
production of inflammatory mediators at the gut level and, via modification of the gut–blood …