Targeting glycogen synthase kinase-3β for Alzheimer's disease: recent advances and future Prospects
Z Cheng, T Han, J Yao, K Wang, X Dong, F Yu… - European Journal of …, 2024 - Elsevier
Senile plaques induced by β-amyloid (Aβ) abnormal aggregation and neurofibrillary tangles
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …
Tanacetum species: Bridging empirical knowledge, phytochemistry, nutritional value, health benefits and clinical evidence
S Khatib, M Sobeh, C Faraloni… - Frontiers in …, 2023 - frontiersin.org
Introduction: The Tanacetum genus consists of 160 accepted flowering species thriving
throughout temperate regions, mainly in the Mediterranean Basin, Northern America, and …
throughout temperate regions, mainly in the Mediterranean Basin, Northern America, and …
A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
Targeting microglia in neuroinflammation: H3 receptor antagonists as a novel therapeutic approach for Alzheimer's disease, Parkinson's disease, and autism spectrum …
Histamine performs dual roles as an immune regulator and a neurotransmitter in the
mammalian brain. The histaminergic system plays a vital role in the regulation of …
mammalian brain. The histaminergic system plays a vital role in the regulation of …
Evidence of disturbed insulin signaling in animal models of Alzheimer's disease
Since glucose reuptake by neurons is mostly independent of insulin, it has been an
intriguing question whether insulin has or not any roles in the brain. Consequently, the …
intriguing question whether insulin has or not any roles in the brain. Consequently, the …
Understanding the journey of biopolymeric nanoformulations for oral drug delivery: Conventional to advanced treatment approaches
The oral route of drug administration offers a convenient, cost-efficient, and non-invasive
means of administering medications. Nevertheless, as newly developed active …
means of administering medications. Nevertheless, as newly developed active …
A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 …
J Guo, M Cheng, P Liu, D Cao, J Luo, Y Wan… - European Journal of …, 2022 - Elsevier
Alzheimer's disease (AD) possessed intricate pathogenesis. Currently, multi-targeted drugs
were considered to have the potential to against AD by simultaneously triggering molecules …
were considered to have the potential to against AD by simultaneously triggering molecules …
Multi-target QSAR modeling for the identification of novel inhibitors against Alzheimer's disease
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, which is the most
common cause of dementia in elderly individuals. It is characterized by selective neuronal …
common cause of dementia in elderly individuals. It is characterized by selective neuronal …
A review of the recent advances in Alzheimer's disease research and the utilization of network biology approaches for prioritizing diagnostics and therapeutics
Alzheimer's disease (AD) is a polygenic multifactorial neurodegenerative disease that, after
decades of research and development, is still without a cure. There are some symptomatic …
decades of research and development, is still without a cure. There are some symptomatic …
Polypharmacology: promises and new drugs in 2022
P Ryszkiewicz, B Malinowska, E Schlicker - Pharmacological Reports, 2023 - Springer
Polypharmacology is an emerging strategy of design, synthesis, and clinical implementation
of pharmaceutical agents that act on multiple targets simultaneously. It should not be mixed …
of pharmaceutical agents that act on multiple targets simultaneously. It should not be mixed …