Tumor cells evolve in a complex and heterogeneous environment composed of different cell
types and an extracellular matrix. Current 2D culture methods are very limited in their ability …

Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …

Mechanical factors play a crucial role in the development of articular cartilage in vivo. In this
regard, tissue engineers have sought to leverage native mechanotransduction pathways to …

Joint-derived stem cells are a promising alternative cell source for cartilage repair therapies
that may overcome many of the problems associated with the use of primary chondrocytes …

Interconnected porosity is critical to the design of regenerative scaffolds, as it permits cell
migration, vascularisation and diffusion of nutrients and regulatory molecules inside the …

The molecular mechanisms of mechanotransduction in regulating mesenchymal stem cell
(MSC) chondrogenesis are not fully understood and represent an area of growing …

It has been proven that the mechanical microenvironment can impact the differentiation of
mesenchymal stem cells (MSCs). However, the effect of mechanical stimuli in biofabricating …

Although hydrogels are extensively investigated as biomaterials due to their ability to mimic
cellular microenvironments, they are often limited by their poor physical properties in …

Mesenchymal stem cells (MSCs) can sense and convert mechanical stimuli signals into a
chemical response. Integrins are involved in the mechanotransduction from inside to outside …

Unlike other malignant bone tumors including osteosarcomas and Ewing sarcomas with a
peak incidence in adolescents and young adults, conventional and dedifferentiated …