Pathomechanism of intervertebral disc degeneration
T Oichi, Y Taniguchi, Y Oshima, S Tanaka, T Saito - JOR spine, 2020 - Wiley Online Library
Intervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a
leading cause of disability worldwide. Although substantial progress has been made in …
leading cause of disability worldwide. Although substantial progress has been made in …
The molecular basis of intervertebral disc degeneration
CK Kepler, RK Ponnappan, CA Tannoury, MV Risbud… - The Spine Journal, 2013 - Elsevier
BACKGROUND: Intervertebral disc (IVD) degeneration remains a clinically important
condition for which treatment is costly and relatively ineffective. The molecular basis of …
condition for which treatment is costly and relatively ineffective. The molecular basis of …
The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration
In this study, we investigated the hypotheses that in human intervertebral disc (IVD)
degeneration there is local production of the cytokine IL-1, and that this locally produced …
degeneration there is local production of the cytokine IL-1, and that this locally produced …
Diversity of intervertebral disc cells: phenotype and function
The intervertebral disc (IVD) is a moderately moving joint that is located between the bony
vertebrae and provides flexibility and load transmission throughout the spinal column. The …
vertebrae and provides flexibility and load transmission throughout the spinal column. The …
Matrix synthesis and degradation in human intervertebral disc degeneration
CL Le Maitre, A Pockert, DJ Buttle… - Biochemical Society …, 2007 - portlandpress.com
Degeneration of the intervertebral disc has been implicated in chronic low back pain. Type II
collagen and proteoglycan (predominantly aggrecan) content is crucial to proper disc …
collagen and proteoglycan (predominantly aggrecan) content is crucial to proper disc …
The cell biology of intervertebral disc aging and degeneration
CQ Zhao, LM Wang, LS Jiang, LY Dai - Ageing research reviews, 2007 - Elsevier
Intervertebral disc degeneration, which mimics disc aging but occurs at an accelerated rate,
is considered to be related to neck or low back pain and disc herniation. Degenerated discs …
is considered to be related to neck or low back pain and disc herniation. Degenerated discs …
Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc
The histological and biochemical changes that occur in the extracellular matrix of the
intervertebral disc (IVD) during ageing and degeneration have been investigated …
intervertebral disc (IVD) during ageing and degeneration have been investigated …
[PDF][PDF] Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc
F Mwale, P Roughley, J Antoniou - Eur Cell Mater, 2004 - researchgate.net
Tissue engineering of intervertebral discs (IVD) using mesenchymal stem cells (MSCs)
induced to differentiate into a disc-cell phenotype has been considered as an alternative …
induced to differentiate into a disc-cell phenotype has been considered as an alternative …
Genetic polymorphisms associated with intervertebral disc degeneration
BACKGROUND CONTEXT: Disc degeneration (DD) is a multifaceted chronic process that
alters the structure and function of the intervertebral discs and can lead to painful conditions …
alters the structure and function of the intervertebral discs and can lead to painful conditions …
[HTML][HTML] Challenges and strategies in the repair of ruptured annulus fibrosus
CC Guterl, EY See, SBG Blanquer… - European cells & …, 2013 - ncbi.nlm.nih.gov
Lumbar discectomy is the surgical procedure most frequently performed for patients
suffering from low back pain and sciatica. Disc herniation as a consequence of degenerative …
suffering from low back pain and sciatica. Disc herniation as a consequence of degenerative …