Mitotic DNA synthesis (MiDAS) is an unusual form of DNA replication that occurs during
mitosis. Initially, MiDAS was characterized as a process associated with intrinsically …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Proteostasis can be disturbed by mutations affecting folding and stability of the encoded
protein. An example is the ubiquitin ligase Parkin, where gene variants result in autosomal …

Parkinson's disease (PD) is a common and incurable neurodegenerative disorder that
arises from the loss of dopaminergic neurons in the substantia nigra and is mainly …

Fidelity in chromosome duplication and segregation is indispensable for maintaining
genomic stability and the perpetuation of life. Challenges to genome integrity jeopardize cell …

Common fragile sites (CFSs) are genomic loci prone to the formation of breaks or gaps on
metaphase chromosomes. They are hotspots for chromosome rearrangements and …

MYC is a transcription factor that controls the expression of a large fraction of cellular genes
linked to cell cycle progression, metabolism and differentiation. MYC deregulation in tumors …

Mutations of SMC5/6 components cause developmental defects, including primary
microcephaly. To model neurodevelopmental defects, we engineered a mouse wherein …

In every cell cycle, billions of nucleotides need to be duplicated within hours, with
extraordinary precision and accuracy. The molecular mechanism by which cells regulate the …

Since their discovery, R-loops have been associated with both physiological and
pathological functions that are conserved across species. R-loops are a source of replication …