Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach …
F Pistollato, F Madia, R Corvi, S Munn, E Grignard… - Archives of …, 2021 - Springer
Abstract The EU Directive 2010/63/EU on the protection of animals used for scientific
purposes and other EU regulations, such as REACH and the Cosmetic Products Regulation …
purposes and other EU regulations, such as REACH and the Cosmetic Products Regulation …
[HTML][HTML] t4 workshop report: State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
N Alépée, A Bahinski, M Daneshian, B De Wever… - Altex, 2014 - ncbi.nlm.nih.gov
Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
[HTML][HTML] Recommendation on test readiness criteria for new approach methods (NAM) in toxicology: exemplified for developmental neurotoxicity (DNT)
A Bal-Price, HT Hogberg, KM Crofton, M Daneshian… - Altex, 2018 - ncbi.nlm.nih.gov
Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …
such new approach methods (NAMs) in a regulatory context, criteria to define their …
Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection …
There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …
posed by industrial and environmental chemicals. New testing approaches will most likely …
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach
Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often
manifest themselves in functional deficits that are not necessarily based on cell death, but …
manifest themselves in functional deficits that are not necessarily based on cell death, but …
Neurotoxicology of nanomaterials
The remarkable advances coming about through nanotechnology promise to revolutionize
many aspects of modern life; however, these advances come with a responsibility for due …
many aspects of modern life; however, these advances come with a responsibility for due …
[HTML][HTML] Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods
A Bal-Price, F Pistollato, M Sachana, SK Bopp… - Toxicology and applied …, 2018 - Elsevier
Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …
[HTML][HTML] Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals
J Blum, S Masjosthusmann, K Bartmann, F Bendt… - Chemosphere, 2023 - Elsevier
Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …
exposome. However, DNT data from animal studies are available for only a small …
Zebrafish as a systems toxicology model for developmental neurotoxicity testing
The develo** brain is extremely sensitive to many chemicals. Exposure to neurotoxicants
during development has been implicated in various neuropsychiatric and neurological …
during development has been implicated in various neuropsychiatric and neurological …