Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
transmission efficiency depends on the correct functionality and expression of a plethora of …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Soluble α-synuclein aggregates varying in size, structure, and morphology have been
closely linked to neuronal death in Parkinson's disease. However, the heterogeneity of …

Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

α-synuclein (α-syn) is a protein associated with the pathogenesis of Parkinson's disease
(PD), the second most common neurodegeneration disease with no effective treatment …

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Adverse intra-and extracellular effects of toxic α-synuclein are believed to be central to the
pathogenesis in Parkinson's disease and other disorders with Lewy body pathology in the …

Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …