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Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
MicroRNAs in cardiovascular disease
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …
RNA-Seq identifies circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as potential biomarkers for acute ischemic stroke
Rationale: Currently, there are no blood-based biomarkers with clinical utility for acute
ischemic stroke (IS). MicroRNAs show promise as disease markers because of their cell type …
ischemic stroke (IS). MicroRNAs show promise as disease markers because of their cell type …
Impact of miRNA in atherosclerosis
e160 Arterioscler Thromb Vasc Biol September 2018 were actively exported to the
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …
MicroRNAs and cardiovascular disease risk
CD Searles - Current Cardiology Reports, 2024 - Springer
Abstract Purpose of Review MicroRNAs (miRNAs)—short, non-coding RNAs—play
important roles in almost all aspects of cardiovascular biology, and changes in intracellular …
important roles in almost all aspects of cardiovascular biology, and changes in intracellular …
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences
Platelets have been shown to be associated with pathophysiological processes beyond
thrombosis, demonstrating critical additional roles in homeostatic processes, such as …
thrombosis, demonstrating critical additional roles in homeostatic processes, such as …
MicroRNA biomarkers and platelet reactivity: the clot thickens
N Sunderland, P Skroblin, T Barwari… - Circulation …, 2017 - ahajournals.org
Over the last few years, several groups have evaluated the potential of microRNAs
(miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss the …
(miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss the …
Fibrin clot properties independently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy
Aims To determine whether fibrin clot properties are associated with clinical outcomes
following acute coronary syndrome (ACS). Methods and results Plasma samples were …
following acute coronary syndrome (ACS). Methods and results Plasma samples were …
Platelet-derived MicroRNAs regulate cardiac remodeling after myocardial ischemia
JP Schütte, MC Manke, K Hemmen, P Münzer… - Circulation …, 2023 - ahajournals.org
Background: Platelets can infiltrate ischemic myocardium and are increasingly recognized
as critical regulators of inflammatory processes during myocardial ischemia and reperfusion …
as critical regulators of inflammatory processes during myocardial ischemia and reperfusion …
Association of cardiometabolic microRNAs with COVID-19 severity and mortality
C Gutmann, K Khamina, K Theofilatos… - Cardiovascular …, 2022 - academic.oup.com
Abstract Aims Coronavirus disease 2019 (COVID-19) can lead to multiorgan damage.
MicroRNAs (miRNAs) in blood reflect cell activation and tissue injury. We aimed to …
MicroRNAs (miRNAs) in blood reflect cell activation and tissue injury. We aimed to …