The ubiquitin–proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders
Y Kitajima, K Yoshioka, N Suzuki - The Journal of Physiological Sciences, 2020 - Springer
Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …
proteasome system (UPS) is recognised as a major intracellular protein degradation system …
2019 FDA TIDES (peptides and oligonucleotides) harvest
2019 has been an excellent year in terms of peptides and oligonucleotides (TIDES)
approved by the FDA. Despite the drop in the number of total drugs approved by the FDA in …
approved by the FDA. Despite the drop in the number of total drugs approved by the FDA in …
Development of in vitro 2D and 3D microelectrode arrays and their role in advancing biomedical research
The development of microelectrode arrays (MEAs) along with complementary advances in
electronics, mechanics and software to connect with these arrays has led to the in vitro …
electronics, mechanics and software to connect with these arrays has led to the in vitro …
Cell clearing systems as targets of polyphenols in viral infections: Potential implications for COVID-19 pathogenesis
F Limanaqi, CL Busceti, F Biagioni, G Lazzeri, M Forte… - Antioxidants, 2020 - mdpi.com
The novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) has generated the ongoing coronavirus disease-2019 (COVID-19) pandemic, still with an …
2) has generated the ongoing coronavirus disease-2019 (COVID-19) pandemic, still with an …
Metformin reverses the enhanced myocardial SR/ER–mitochondria interaction and impaired complex I-driven respiration in dystrophin-deficient mice
C Angebault, M Panel, M Lacôte, J Rieusset… - Frontiers in Cell and …, 2021 - frontiersin.org
Besides skeletal muscle dysfunction, Duchenne muscular dystrophy (DMD) exhibits a
progressive cardiomyopathy characterized by an impaired calcium (Ca2+) homeostasis and …
progressive cardiomyopathy characterized by an impaired calcium (Ca2+) homeostasis and …
Therapeutic aspects of cell signaling and communication in Duchenne muscular dystrophy
A Starosta, P Konieczny - Cellular and Molecular Life Sciences, 2021 - Springer
Duchenne muscular dystrophy (DMD) is a devastating chromosome X-linked disease that
manifests predominantly in progressive skeletal muscle wasting and dysfunctions in the …
manifests predominantly in progressive skeletal muscle wasting and dysfunctions in the …
TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy
D Xu, S Li, L Wang, J Jiang, L Zhao… - Journal of cachexia …, 2021 - Wiley Online Library
Background Transforming growth factor‐β‐activated kinase 1 (TAK1) plays a key role in
regulating fibroblast and myoblast proliferation and differentiation. However, the TAK1 …
regulating fibroblast and myoblast proliferation and differentiation. However, the TAK1 …
Immunoproteasome inhibition ameliorates aged dystrophic mouse muscle environment
L Tripodi, D Molinaro, F Fortunato, C Mella… - International Journal of …, 2022 - mdpi.com
Muscle wasting is a major pathological feature observed in Duchenne muscular dystrophy
(DMD) and is the result of the concerted effects of inflammation, oxidative stress and cell …
(DMD) and is the result of the concerted effects of inflammation, oxidative stress and cell …
Systemically administered homing peptide targets dystrophic lesions and delivers transforming growth factor-β (TGFβ) inhibitor to attenuate murine muscular …
Muscular dystrophy is a progressively worsening and lethal disease, where accumulation of
functionality-impairing fibrosis plays a key pathogenic role. Transforming growth factor-β1 …
functionality-impairing fibrosis plays a key pathogenic role. Transforming growth factor-β1 …
Cardiac proteostasis in obesity and cardiovascular disease
Cardiovascular diseases (CVD) are closely linked to protein homeostasis (proteostasis) and
its failure. Beside genetic mutations that impair cardiac protein quality control, obesity is a …
its failure. Beside genetic mutations that impair cardiac protein quality control, obesity is a …