Hepatocyte nuclear factor 4α (HNF4α), a member of the nuclear receptor superfamily, is
described as a protein that binds to the promoters of specific genes. It controls the …

Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear
receptor superfamily of ligand-dependent transcription factors that is expressed in liver and …

Cellular metabolism plays important functions in dictating stem cell behaviors, although its
role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that …

Cancer cells are usually exposed to stressful environments, such as hypoxia, nutrient
deprivation, and other metabolic dysfunctional regulation, leading to continuous …

In the more than 30 years since the purification and cloning of Hepatocyte Nuclear Factor 4
(HNF4α), considerable insight into its role in liver function has been gleaned from its target …

In pyloric metaplasia, mature gastric chief cells reprogram via an evolutionarily conserved
process termed paligenosis to re-enter the cell cycle and become spasmolytic polypeptide …

Abstract Phosphomannomutase 2 (PMM2) deficiency causes Congenital Disorder of
Glycosylation (PMM2-CDG), but does not have a recognised association with Inflammatory …

Objective Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a 5-
year survival of less than 5%. Transcriptomic analysis has identified two clinically relevant …

The gastroesophageal squamocolumnar junction (GE-SCJ) is a critical tissue interface
between the esophagus and stomach, with significant relevance in the pathophysiology of …

Objective Gastric cancer (GC) is a leading cause of cancer mortality. Previous studies have
shown that hepatocyte nuclear factor-4α (HNF4α) is specifically overexpressed in GC and …