Antibiotics and other agents that perturb the synthesis or integrity of the bacterial cell
envelope trigger compensatory stress responses. Focusing on Bacillus subtilis as a model …

Two-component systems (TCSs) are a ubiquitous family of signal transduction pathways that
enable bacteria to sense and respond to physical, chemical, and biological stimuli outside …

There is an urgent need to develop novel antibiotics since antibiotic resistance is an
increasingly serious threat to global public health. Whole-cell biosensors are one of the …

Whole-cell biosensors are emerging as promising tools for monitoring environmental
pollutants such as heavy metals. These sensors constitute a genetic circuit comprising a …

Cell envelope-targeting antibiotics are potent therapeutic agents against various bacterial
infections. The emergence of multiple antibiotic-resistant strains underscores the …

Spherical dendrimers and dendrons containing silver (I) N-heterocyclic carbenes (Ag (I)-
NHC) and additionally bow-tie metal-free dendritic systems were synthesized in a simple …

Fungal infections pose a growing public health threat, creating an urgent clinical need for
new antifungals. Natural products (NPs) from organisms in extreme environments are a …

Over the course of the last decades, the continuous exposure of bacteria to antibiotics—at
least in parts due to misprescription, misuse, and misdosing—has led to the widespread …

The identification of an increasing number of drug-resistant pathogens has stimulated the
development of new therapeutic agents to combat them. Microbial natural products are …

Efficient control of transcription is essential in all organisms. In bacteria, where DNA
replication and transcription occur simultaneously, the replication machinery is at risk of …