Resveratrol is the most well-known polyphenolic stilbenoid, present in grapes, mulberries,
peanuts, rhubarb, and in several other plants. Resveratrol can play a beneficial role in the …

Sirtuin is an essential factor that delays cellular senescence and extends the organismal
lifespan through the regulation of diverse cellular processes. Suppression of cellular …

Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent deacetylase, is
a cellular regulator that has received extensive attention in recent years and regarded as a …

Ageing is a major risk factor for develo** many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Sirtuins are a family of NAD+-dependent deacylases with numerous physiological and
pathological implications, which lately became an attractive therapeutic target. Sirtuin …

The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …

Plants containing resveratrol have been used effectively in traditional medicine for over
2000 years. It can be found in some plants, fruits, and derivatives, such as red wine …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but
whether SIRT1 mediates these benefits is the subject of debate. To circumvent the …

SIRT6, a member of the SIRT deacetylase family, is responsible for deacetylation of histone
H3 N ε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac). As a tumor suppressor, SIRT6 has …