Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

Humans can recognise five basic tastes: sweet, sour, salty, bitter and umami. Sour and salty
substances are linked to ion channels, while sweet, bitter and umami flavours are …

The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as
ornamental plants. These plants are also valued in traditional medicine. Among all Papaver …

The human GPCR family comprises circa 800 members, activated by hundreds of thousands
of compounds. Bitter taste receptors, TAS2Rs, constitute a large and distinct subfamily …

Introduction Several studies have shown anti-tumor effects of components present in
cannabis in different models. Unfortunately, little is known about the potential anti-tumoral …

Pharmacoresistance of cancer cells to many drugs used in chemotherapy remains a major
challenge for the treatment of cancer. Multidrug resistance transporters, especially ATP …

Heart diseases and related complications constitute a leading cause of death and
socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic …

Simple Summary Bitter taste receptors (TAS2Rs) are functionally expressed in various extra-
oral cells eliciting non-gustatory functions. In the context of cancer, their functionality is less …

The human genome contains∼ 29 bitter taste receptors (T2Rs), which are responsible for
detecting thousands of bitter ligands, including toxic and aversive compounds. This sentinel …

Introduction With the legalization of cannabis in multiple jurisdictions throughout the world, a
larger proportion of the population consumes cannabis. Several studies have demonstrated …