Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease
Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …
miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …
Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice
C Ushiroda, Y Naito, T Takagi, K Uchiyama… - Journal of clinical …, 2019 - jstage.jst.go.jp
抄録 Gut microbiota have profound effects on bile acid metabolism by promoting
deconjugation, dehydrogenation, and dehydroxylation of primary bile acids in the distal …
deconjugation, dehydrogenation, and dehydroxylation of primary bile acids in the distal …
[HTML][HTML] Bile acids and cancer: direct and environmental-dependent effects
Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but
have also a key role as signaling molecules and in the modulation of epithelial cell …
have also a key role as signaling molecules and in the modulation of epithelial cell …
Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis
J Yu, S Li, J Guo, Z Xu, J Zheng, X Sun - Cell Death & Disease, 2020 - nature.com
Farnesoid X receptor (FXR, encoded by NR1H4), a critical regulator of bile acid
homeostasis, is widely implicated in human tumorigenesis. However, the functional role of …
homeostasis, is widely implicated in human tumorigenesis. However, the functional role of …
Targeting Farnesoid X receptor (FXR) for develo** novel therapeutics against cancer
Cancer is one of the lethal diseases that arise due to the molecular alterations in the cell.
One of those alterations associated with cancer corresponds to differential expression of …
One of those alterations associated with cancer corresponds to differential expression of …
[PDF][PDF] Highly sensitive circulating microRNA panel for accurate detection of hepatocellular carcinoma in patients with liver disease
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer deaths worldwide.
The high mortality rate in HCC is largely due to the difficulty of early detection. In this study …
The high mortality rate in HCC is largely due to the difficulty of early detection. In this study …
MicroRNA-92a-1–5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia
T Li, H Guo, H Li, Y Jiang, K Zhuang, C Lei, J Wu… - Gut, 2019 - gut.bmj.com
Background and aims Gastric intestinal metaplasia (IM) is common in the gastric epithelium
of patients with chronic atrophic gastritis. CDX2 activation in IM is driven by reflux of bile …
of patients with chronic atrophic gastritis. CDX2 activation in IM is driven by reflux of bile …
Differential role of microRNAs in the pathogenesis and treatment of Esophageal cancer
Esophageal cancer (EC) is the most invasive disease associated with inclusive poor
prognosis. EC usually is found as either adenocarcinoma (EAC) or squamous cell …
prognosis. EC usually is found as either adenocarcinoma (EAC) or squamous cell …
Extracellular microRNAs and oxidative stress in liver injury: a systematic mini review
J Matsuzaki, T Ochiya - Journal of Clinical Biochemistry and Nutrition, 2018 - jstage.jst.go.jp
抄録 Recent evidence has suggested that extracellular microRNAs have crucial roles in
intercellular communications and are promising as minimally invasive biomarkers for …
intercellular communications and are promising as minimally invasive biomarkers for …