Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis
ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2).
ROS are typically produced under physiological conditions and play crucial roles in living …
ROS are typically produced under physiological conditions and play crucial roles in living …
The promise of nanoparticles-based radiotherapy in cancer treatment
Simple Summary Radiotherapy (RT) is used worldwide as a gold standard treatment
approach for cancer management. However, the RT treatment modality contains limitations …
approach for cancer management. However, the RT treatment modality contains limitations …
[HTML][HTML] Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma
F Villarruel-Melquiades… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumours worldwide. The
mortality-to-incidence ratio is up to 91.6% in many countries, representing the third leading …
mortality-to-incidence ratio is up to 91.6% in many countries, representing the third leading …
Interweaving catalysis and cancer using Ru-and Os-arene complexes to alter cellular redox state: A structure-activity relationship (SAR) review
The field of bioorganometallic chemistry has expanded significantly in the recent past.
Organometallic complexes have offered up new opportunities as efficient catalysts (such as …
Organometallic complexes have offered up new opportunities as efficient catalysts (such as …
Insights into the Theranostic Activity of Nonoxido VIV: Lysosome-Targeted Anticancer Metallodrugs
Develo** new anticancer agents can be useful, with the ability to diagnose and treat
cancer worldwide. Previously, we focused on examining the effects of nonoxidovanadium …
cancer worldwide. Previously, we focused on examining the effects of nonoxidovanadium …
Mitochondria's role in the maintenance of cancer stem cells in hepatocellular carcinoma
MA Elhinnawi, MI Boushra, DM Hussien… - Stem Cell Reviews and …, 2024 - Springer
Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and is recognized
as a major contributor to cancer-related mortality worldwide. Cancer stem cells (CSCs) are a …
as a major contributor to cancer-related mortality worldwide. Cancer stem cells (CSCs) are a …
TGF-β in correlation with tumor progression, immunosuppression and targeted therapy in colorectal cancer
Colorectal cancer (CRC) is a complex malignancy responsible for the second-highest
cancer deaths worldwide. TGF-β maintains normal cellular homeostasis by inhibiting the cell …
cancer deaths worldwide. TGF-β maintains normal cellular homeostasis by inhibiting the cell …
[HTML][HTML] Targeting the SMURF2-HIF1α axis: a new frontier in cancer therapy
E Youssef, S Zhao, C Purcell, GL Olson… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
The SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) has emerged as a critical
regulator in cancer biology, modulating the stability of Hypoxia-Inducible Factor 1-alpha …
regulator in cancer biology, modulating the stability of Hypoxia-Inducible Factor 1-alpha …
Nanoparticle-based antioxidants in stress signaling and programmed cell death in breast cancer treatment
Breast cancer (BC) is a complex and heterogeneous disease, and oxidative stress is a
hallmark of BC. Oxidative stress is characterized by an imbalance between the production of …
hallmark of BC. Oxidative stress is characterized by an imbalance between the production of …