Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Z Luo, M Tian, G Yang, Q Tan, Y Chen, G Li… - Signal transduction and …, 2022 - nature.com
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis

HS Tuli, J Kaur, K Vashishth, K Sak, U Sharma… - Archives of …, 2023 - Springer
ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2).
ROS are typically produced under physiological conditions and play crucial roles in living …

The promise of nanoparticles-based radiotherapy in cancer treatment

M Haque, MS Shakil, KM Mahmud - Cancers, 2023 - mdpi.com
Simple Summary Radiotherapy (RT) is used worldwide as a gold standard treatment
approach for cancer management. However, the RT treatment modality contains limitations …

[HTML][HTML] Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma

F Villarruel-Melquiades… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumours worldwide. The
mortality-to-incidence ratio is up to 91.6% in many countries, representing the third leading …

Interweaving catalysis and cancer using Ru-and Os-arene complexes to alter cellular redox state: A structure-activity relationship (SAR) review

S Swaminathan, RJ Deepak, R Karvembu - Coordination Chemistry …, 2023 - Elsevier
The field of bioorganometallic chemistry has expanded significantly in the recent past.
Organometallic complexes have offered up new opportunities as efficient catalysts (such as …

Insights into the Theranostic Activity of Nonoxido VIV: Lysosome-Targeted Anticancer Metallodrugs

PD Pattanayak, A Banerjee, G Sahu, S Das… - Inorganic …, 2024 - ACS Publications
Develo** new anticancer agents can be useful, with the ability to diagnose and treat
cancer worldwide. Previously, we focused on examining the effects of nonoxidovanadium …

Mitochondria's role in the maintenance of cancer stem cells in hepatocellular carcinoma

MA Elhinnawi, MI Boushra, DM Hussien… - Stem Cell Reviews and …, 2024 - Springer
Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and is recognized
as a major contributor to cancer-related mortality worldwide. Cancer stem cells (CSCs) are a …

TGF-β in correlation with tumor progression, immunosuppression and targeted therapy in colorectal cancer

S Singh, V Gouri, M Samant - Medical Oncology, 2023 - Springer
Colorectal cancer (CRC) is a complex malignancy responsible for the second-highest
cancer deaths worldwide. TGF-β maintains normal cellular homeostasis by inhibiting the cell …

[HTML][HTML] Targeting the SMURF2-HIF1α axis: a new frontier in cancer therapy

E Youssef, S Zhao, C Purcell, GL Olson… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
The SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) has emerged as a critical
regulator in cancer biology, modulating the stability of Hypoxia-Inducible Factor 1-alpha …

Nanoparticle-based antioxidants in stress signaling and programmed cell death in breast cancer treatment

Y Herdiana, S Sriwidodo, FF Sofian, G Wilar, A Diantini - Molecules, 2023 - mdpi.com
Breast cancer (BC) is a complex and heterogeneous disease, and oxidative stress is a
hallmark of BC. Oxidative stress is characterized by an imbalance between the production of …