Introduction For the past two decades, virtual screening (VS) has been an efficient hit finding
approach for drug discovery. Today, billions of commercially accessible compounds are …

Cancer immunotherapy, leveraging antibodies, excels in targeting efficacy but faces hurdles
in tissue penetration, oral delivery, and prolonged half-life, with costly production and risk of …

Small-molecule modulators of immune checkpoints are poised to revolutionize cancer
immunotherapy. However, efficient strategies for hit identification are lacking. We introduce …

Simple Summary Glioblastoma (GBM) is an aggressive brain tumor with limited treatment
success. Despite efforts, the prognosis remains poor, impacting patients' quality of life …

Introduction Targeting immune checkpoint proteins (ICPs) via small molecules open a new
window for cancer immunotherapy. Herein, we summarize recent advances of small …

Blocking the immunosuppressive function of T-cell immunoglobulin mucin-3 (TIM-3) is an
established therapeutic strategy to maximize the efficacy of immune checkpoint inhibitors for …

Compared to small molecules and antibodies, cyclic peptides exhibit unique biochemical
and therapeutic attributes in the realm of pharmaceutical applications. The interaction …

Herein, we performed a virtual screening study to discover new scaffolds for small molecule-
based ligands of the immune checkpoint lymphocyte-activation gene 3 (LAG-3). Molecular …

Immune checkpoint inhibitors (ICIs) are used to relieve and refuel anti-tumor immunity by
blocking the interaction, transcription, and translation of co-inhibitory immune checkpoints or …

Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) is a membrane
protein that plays an important role in a variety of immune and non‐immune functions. Such …