The μ-opioid receptor (μOR), a prototypical G protein-coupled receptor (GPCR), is the target
of opioid analgesics such as morphine and fentanyl. Due to the severe side effects of current …

The XC motif chemokine receptor XCR1, which selectively binds to the chemokine XCL1, is
highly expressed in conventional dendritic cells subtype 1 (cDC1s) and crucial for their …

There is increasing evidence that β1-adrenoreceptor autoantibody (β1AR-AAb) elimination
can break the vicious circle induced by certain pathological conditions associated with …

Chemokine stimulation of atypical chemokine receptor 3 (ACKR3) does not activate G
proteins but recruits arrestins. It is a chemokine scavenger that indirectly influences …

The development of engineered biologics as both tools and therapeutic molecules have
transformed the scientific landscape tremendously. Due to their increased specificity …

(+)-Pleuromutilin is a fungal natural product that binds to the peptidyl transferase center of
bacterial ribosomes, inhibiting protein synthesis as its mechanism of action. This tricyclic …

The development of engineered biologics as both tools and therapeutic molecules have
transformed the scientific landscape tremendously. Due to their increased specificity …