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Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine
Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …
recognition of its significance, immune status monitoring is not implemented in clinical …
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …
priority. There has been a tremendous effort to decipher underlying mechanisms …
Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis
J Carvelli, O Demaria, F Vély, L Batista… - Nature, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic …
Acute respiratory distress syndrome
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …
Acute renal failure and sepsis
RW Schrier, W Wang - New England Journal of Medicine, 2004 - Mass Medical Soc
Acute Renal Failure and Sepsis | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
[HTML][HTML] Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
Sepsis and sepsis syndrome are leading causes of mortality throughout the world. It is
widely held that sepsis represents a dysregulated innate immune response to an offending …
widely held that sepsis represents a dysregulated innate immune response to an offending …
Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
Inflammatory response leading to organ dysfunction and failure continues to be the major
problem after injury in many clinical conditions such as sepsis, severe burns, acute …
problem after injury in many clinical conditions such as sepsis, severe burns, acute …
Update on mechanisms of ischemic acute kidney injury
Acute renal failure (ARF), classically defined as an abrupt decrease in kidney function that
leads to accumulation of nitrogenous wastes such as blood urea nitrogen and creatinine, is …
leads to accumulation of nitrogenous wastes such as blood urea nitrogen and creatinine, is …
Role of C5a in inflammatory responses
RF Guo, PA Ward - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract The complement system not only represents an effective innate immune
mechanism of host defense to eradicate microbial pathogens, but it is also widely involved in …
mechanism of host defense to eradicate microbial pathogens, but it is also widely involved in …
Host–pathogen interactions in sepsis
T van der Poll, SM Opal - The Lancet infectious diseases, 2008 - thelancet.com
Sepsis is a major health problem. The concept that sepsis mortality is the result of an
uncontrolled hyperinflammatory host response has recently been challenged. It is now …
uncontrolled hyperinflammatory host response has recently been challenged. It is now …