During Parkinson's disease (PD), both the central nervous system (CNS) and peripheral
nervous system (PNS) are affected. In parallel, innate immune cells respond early to …

Parkinson's disease is characterized neuropathologically by the degeneration of
dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) …

Given the chronic inflammatory nature of Parkinson's disease (PD), T cell immunity may be
important for disease onset. Here, we performed single-cell transcriptome and TCR …

Immune system plays important roles in the pathogenesis of Parkinson's disease (PD).
However, the role of B cells in this complex disease are still not fully understood. B cells …

The clinical presentation of Parkinson's disease (PD) is both complex and heterogeneous,
and its precise classification often requires an intensive work-up. The differential diagnosis …

Aging leads to escalated systemic inflammation. As the sentinel of immune system, natural
killer (NK) cells are early responders that sense cues and signals from target organs and …

T cells are key mediators of both humoral and cellular adaptive immune responses, and
their role in Parkinson's disease (PD) is being increasingly recognized. Several lines of …

The recent validation of the α-synuclein seed amplification assay as a biomarker with high
sensitivity and specificity for the diagnosis of Parkinson's disease has formed the backbone …

Parkinson's disease (PD) is a progressive, neurodegenerative condition of the central
nervous system (CNS) affecting 6.3 million people worldwide with no curative treatments …

Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease. Inflammation has been observed in both the idiopathic and familial …