Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis
Covering: 1997 to 2010 The angucycline group is the largest group of type II PKS-
engineered natural products, rich in biological activities and chemical scaffolds. This …
engineered natural products, rich in biological activities and chemical scaffolds. This …
Nonenzymatic reactions in natural product formation
LM Bouthillette, V Aniebok, DA Colosimo… - Chemical …, 2022 - ACS Publications
Biosynthetic mechanisms of natural products primarily depend on systems of protein
catalysts. However, within the field of biosynthesis, there are cases in which the inherent …
catalysts. However, within the field of biosynthesis, there are cases in which the inherent …
Biosynthesis of Polyketides in Streptomyces
Polyketides are a large group of secondary metabolites that have notable variety in their
structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial …
structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial …
Bioactive secondary metabolites from octocoral-associated microbes—new chances for blue growth
Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products
with fascinating and unusual chemical structures and bioactivities of interest to medicine and …
with fascinating and unusual chemical structures and bioactivities of interest to medicine and …
Activating secondary metabolism with stress and chemicals
V Yoon, JR Nodwell - Journal of Industrial Microbiology and …, 2014 - academic.oup.com
The available literature on the secondary or nonessential metabolites of the streptomycetes
bacteria suggests that there may be poorly expressed or “cryptic” compounds that have yet …
bacteria suggests that there may be poorly expressed or “cryptic” compounds that have yet …
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes
Background GlnR is an atypical response regulator found in actinomycetes that modulates
the transcription of genes in response to changes in nitrogen availability. We applied a …
the transcription of genes in response to changes in nitrogen availability. We applied a …
Angucyclines as signals modulate the behaviors of Streptomyces coelicolor
The angucycline antibiotic jadomycin B (JdB) produced by Streptomyces venezuelae has
been found here to induce complex survival responses in Streptomyces coelicolor at …
been found here to induce complex survival responses in Streptomyces coelicolor at …
A unified strategy to access 2-and 4-deoxygenated sugars enabled by manganese-promoted 1, 2-radical migration
HM Carder, CE Suh, AE Wendlandt - Journal of the American …, 2021 - ACS Publications
The selective manipulation of carbohydrate scaffolds is challenging due to the presence of
multiple, nearly chemically indistinguishable O–H and C–H bonds. As a result, protecting …
multiple, nearly chemically indistinguishable O–H and C–H bonds. As a result, protecting …
Selective transformations of carbohydrates inspired by radical-based enzymatic mechanisms
CE Suh, HM Carder, AE Wendlandt - ACS Chemical Biology, 2021 - ACS Publications
Enzymes are a longstanding source of inspiration for synthetic reaction development.
However, enzymatic reactivity and selectivity are frequently untenable in a synthetic context …
However, enzymatic reactivity and selectivity are frequently untenable in a synthetic context …
Modulation of the central carbon metabolism of Corynebacterium glutamicum improves malonyl‐CoA availability and increases plant polyphenol synthesis
L Milke, P Ferreira, N Kallscheuer… - Biotechnology and …, 2019 - Wiley Online Library
In recent years microorganisms have been engineered towards synthesizing interesting
plant polyphenols such as flavonoids and stilbenes from glucose. Currently, the low …
plant polyphenols such as flavonoids and stilbenes from glucose. Currently, the low …