Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …
socioeconomic implications for patients and their care-givers. Recent advances in medical …
The biology of regeneration failure and success after spinal cord injury
AP Tran, PM Warren, J Silver - Physiological reviews, 2018 - journals.physiology.org
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
PTPσ is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration
Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration.
However, no specific receptor for the inhibitory effect of CSPGs has been identified. We …
However, no specific receptor for the inhibitory effect of CSPGs has been identified. We …
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult
central nervous system and their digestion with chondroitinase reactivates plasticity …
central nervous system and their digestion with chondroitinase reactivates plasticity …
[HTML][HTML] Glial cells shape pathology and repair after spinal cord injury
Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he
correctly surmised that microglia in pathologic central nervous system (CNS) were …
correctly surmised that microglia in pathologic central nervous system (CNS) were …
Extracellular matrix and perineuronal nets in CNS repair
JCF Kwok, G Dick, D Wang… - Developmental …, 2011 - Wiley Online Library
A perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the
soma and dendrites, and in some cases the axon initial segments, in sub‐populations of …
soma and dendrites, and in some cases the axon initial segments, in sub‐populations of …
The perineuronal net and the control of CNS plasticity
D Wang, J Fawcett - Cell and tissue research, 2012 - Springer
Perineuronal nets (PNNs) are reticular structures that surround the cell body of many
neurones, and extend along their dendrites. They are considered to be a specialized …
neurones, and extend along their dendrites. They are considered to be a specialized …
Manipulating the glial scar: chondroitinase ABC as a therapy for spinal cord injury
EJ Bradbury, LM Carter - Brain research bulletin, 2011 - Elsevier
Chondroitin sulphate proteoglycans (CSPGs) are potent inhibitors of growth in the adult
CNS. Use of the enzyme chondroitinase ABC (ChABC) as a strategy to reduce CSPG …
CNS. Use of the enzyme chondroitinase ABC (ChABC) as a strategy to reduce CSPG …
Targeting the neural extracellular matrix in neurological disorders
The extracellular matrix (ECM) is known to regulate important processes in neuronal cell
development, activity and growth. It is associated with the structural stabilization of neuronal …
development, activity and growth. It is associated with the structural stabilization of neuronal …
Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following …
Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here
we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via …
we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via …