Redox regulation of the immune response

G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022‏ - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … reviews Molecular cell …, 2022‏ - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

Immunoregulation in diabetic wound repair with a photoenhanced glycyrrhizic acid hydrogel scaffold

Y Qian, Y Zheng, J **, X Wu, K Xu, M Dai… - Advanced …, 2022‏ - Wiley Online Library
M1 macrophage accumulation and excessive inflammation are commonly encountered
issues in diabetic wounds and can fail in the healing process. Hence, hydrogel dressings …

Macrophage polarization and metabolism in atherosclerosis

P Hou, J Fang, Z Liu, Y Shi, M Agostini… - Cell death & …, 2023‏ - nature.com
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

Systemic lupus erythematosus pathogenesis: interferon and beyond

S Caielli, Z Wan, V Pascual - Annual review of immunology, 2023‏ - annualreviews.org
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction

S Cai, M Zhao, B Zhou, A Yoshii, D Bugg, O Villet… - The Journal of clinical …, 2023‏ - jci.org
Innate immune cells play important roles in tissue injury and repair following acute
myocardial infarction (MI). Although reprogramming of macrophage metabolism has been …

Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis

SK Wculek, I Heras-Murillo, A Mastrangelo, D Mañanes… - Immunity, 2023‏ - cell.com
In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

The assembly, regulation and function of the mitochondrial respiratory chain

I Vercellino, LA Sazanov - Nature reviews Molecular cell biology, 2022‏ - nature.com
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

Redox metabolism: ROS as specific molecular regulators of cell signaling and function

C Lennicke, HM Cochemé - Molecular cell, 2021‏ - cell.com
Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …

Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

LK Billingham, JS Stoolman, K Vasan… - Nature …, 2022‏ - nature.com
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …