Antitumor properties of podophyllotoxin and related compounds.
M Gordaliza, MA Castro… - Current …, 2000 - ingentaconnect.com
The lignan family of natural products includes compounds with important antineoplastic and
antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives …
antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives …
Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin
DL Sackett - Pharmacology & therapeutics, 1993 - Elsevier
A large number of antimicrotubule agents are known that bind to tubulin in vitro and disrupt
microtubule assembly in vitro and in vivo. Many of these agents bind to the same site on the …
microtubule assembly in vitro and in vivo. Many of these agents bind to the same site on the …
Organocatalytic Domino Oxa‐Michael/1, 6‐Addition Reactions: Asymmetric Synthesis of Chromans Bearing Oxindole Scaffolds
K Zhao, Y Zhi, T Shu, A Valkonen… - Angewandte …, 2016 - Wiley Online Library
An asymmetric organocatalytic domino oxa‐Michael/1, 6‐addition reaction of ortho‐
hydroxyphenyl‐substituted para‐quinone methides and isatin‐derived enoates has been …
hydroxyphenyl‐substituted para‐quinone methides and isatin‐derived enoates has been …
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain
R Bai, GR Petit, E Hamel - Biochemical pharmacology, 1990 - Elsevier
Dolastatin 10, a cytostatic peptide containing several unique amino acid subunits, was
isolated from the marine shell-less mollusk Dolabella auricularia (Pettit GR, Kamano Y …
isolated from the marine shell-less mollusk Dolabella auricularia (Pettit GR, Kamano Y …
[PDF][PDF] Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.
CM Lin, SB Singh, PS Chu, RO Dempcy… - Molecular …, 1988 - Citeseer
Combretastatin, an antmneoplastic and antmmmtotmc agent, was isolated from the bark of
Combretum caifrum [Can. J. Chem. 60: 1374-1376(1982); Biochem. Pharmacol. 32: 3864 …
Combretum caifrum [Can. J. Chem. 60: 1374-1376(1982); Biochem. Pharmacol. 32: 3864 …
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization
M Cushman, D Nagarathnam, D Gopal… - Journal of medicinal …, 1991 - ACS Publications
This compound was found to cause mitotic arrest in L1210 murine leukemia cells, inhibit
tubulin polymerization, and competitively inhibit the binding of radiolabeled colchicine to …
tubulin polymerization, and competitively inhibit the binding of radiolabeled colchicine to …
[HTML][HTML] Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
RL Bai, GR Pettit, E Hamel - Journal of Biological Chemistry, 1990 - Elsevier
Dolastatin 10, a potent antimitotic peptide from a marine animal, strongly inhibits microtubule
assembly, tubulin-dependent GTP hydrolysis, and the binding of vinca alkaloids to tubulin. In …
assembly, tubulin-dependent GTP hydrolysis, and the binding of vinca alkaloids to tubulin. In …
Synthesis and biological evaluation of 2-styrylquinazolin-4 (3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization
JB Jiang, DP Hesson, BA Dusak… - Journal of medicinal …, 1990 - ACS Publications
A novel series of 2-styrylquinazolin-4 (3H)-ones which inhibited tubulin polymerization and
the growthof L1210 murine leukemiacells was discovered. Extensive structure-activity …
the growthof L1210 murine leukemiacells was discovered. Extensive structure-activity …
Synthesis and evaluation of analogs of (Z)-1-(4-methoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) ethene as potential cytotoxic and antimitotic agents
M Cushman, D Nagarathnam, D Gopal… - Journal of medicinal …, 1992 - ACS Publications
A series of stilbenes has been prepared and tested for cytotoxicity in the five human cancer
cell lines A-549 non-small cell lung, MCF-7 breast, HT-29 colon, SKMEL-5 melanoma, and …
cell lines A-549 non-small cell lung, MCF-7 breast, HT-29 colon, SKMEL-5 melanoma, and …
Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin
K Yoshimatsu, A Yamaguchi, H Yoshino, N Koyanagi… - Cancer Research, 1997 - AACR
Abstract E7010 (N-[2-[(4-hydroxyphenyl) amino]-3pyridinyl]-4-methoxybenzenesulfonamide)
, an orally active sulfonamide antitumor agent that is currently in a Phase I clinical trial …
, an orally active sulfonamide antitumor agent that is currently in a Phase I clinical trial …