Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

ABC (ATP-binding cassette) transporters represent one of the largest and most diverse
superfamily of proteins in living species, playing an important role in many biological …

Chemotherapy‐induced cognitive impairment (“chemobrain”) is a frequent side‐effect in
cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX …

Purpose: Brain metastases of breast cancer appear to be increasing in incidence, confer
significant morbidity, and threaten to compromise gains made in systemic chemotherapy …

Paclitaxel is one of the most effective chemotherapeutic drugs ever developed and is active
against a broad range of cancers, such as lung, ovarian, and breast cancers. Due to its low …

Resistance to drug treatment is an important hurdle in the therapy of many brain disorders,
including brain cancer, epilepsy, schizophrenia, depression and infection of the brain with …

Background and purpose: Paclitaxel is highly efficacious in the treatment of breast, head
and neck, non‐small cell lung cancers and ovarian carcinoma. For malignant gliomas …

Despite the advances in tumor therapy, patients with primary brain tumors and brain
metastases have a very poor prognosis. Low responses to chemotherapy are mainly …

Cancer is a disease that can cause abnormal cell growth and can spread throughout the
body. It is among the most significant causes of death worldwide, resulting in approx. 10 …

The ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp) and ABCG2 are
multidrug transporters that confer drug resistance to numerous anti-cancer therapeutics in …