[HTML][HTML] Therapeutic potential of 4-substituted coumarins: A conspectus
Substituted coumarins are a very large family of naturally occurring compounds, and
substituted coumarins are versatile scaffolds for the development of medicinally active …
substituted coumarins are versatile scaffolds for the development of medicinally active …
Anti-Alzheimer activity of new coumarin-based derivatives targeting acetylcholinesterase inhibition
New 2-oxo-chromene-7-oxymethylene acetohydrazide derivatives 4a–d were designed and
synthesized with a variety of bioactive chemical fragments. The newly synthesized …
synthesized with a variety of bioactive chemical fragments. The newly synthesized …
Chromenone: An emerging scaffold in anti-Alzheimer drug discovery
U Agarwal, S Verma, RK Tonk - Bioorganic & Medicinal Chemistry Letters, 2024 - Elsevier
Alzheimer's disease (AD) presents a growing global health concern. In recent decades,
natural and synthetic chromenone have emerged as promising drug candidates due to their …
natural and synthetic chromenone have emerged as promising drug candidates due to their …
Investigation of novel benzoxazole-oxadiazole derivatives as effective anti-Alzheimer's agents: in vitro and in silico approaches
Alzheimer's disease (AD) is a progressive neurological illness that is distinguished clinically
by cognitive and memory decline and adversely affects the people of old age. The …
by cognitive and memory decline and adversely affects the people of old age. The …
Exploring target site interactions of 1, 3, 4-Oxadiazole/1, 3, 4-thiadiazole derivatives: Synthesis, characterization in vitro anti-urease and in silico molecular docking …
Urease enzyme is one of the major causes of severe health issues including urinary catheter
encrustation, gastric cancer, duodenal ulcer and peptic ulcer. In search for potent anti …
encrustation, gastric cancer, duodenal ulcer and peptic ulcer. In search for potent anti …
Molecular modeling, synthesis, and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activities of novel benzimidazole-bearing thiadiazole derivatives
A new series of benzimidazole-based thiadiazole hybrids analogues (6a–p) as effective
Alzheimer's inhibitors were synthesized and then evaluated for their inhibition profile against …
Alzheimer's inhibitors were synthesized and then evaluated for their inhibition profile against …
Synthesis, biological evaluation, molecular docking, and MD simulation of novel 2, 4-disubstituted quinazoline derivatives as selective butyrylcholinesterase inhibitors …
S Sadeghian, R Razmi, S Khabnadideh… - Scientific Reports, 2024 - nature.com
Alzheimer's disease is the most prevalent neurodegenerative disorder characterized by
significant memory loss and cognitive impairments. Studies have shown that the expression …
significant memory loss and cognitive impairments. Studies have shown that the expression …
[3+ 2] Cycloaddition Synthesis of New (Chromene‐1, 3, 4‐Oxadiazole) Hybrids Linked to Pyrazole Units as Potential Acetylcholinesterase Inhibitors
A lot of interest has been gained recently in develo** novel acetylcholinesterase (AChE)
inhibitors that can alleviate Alzheimer's symptoms. In the current study, we aimed to explore …
inhibitors that can alleviate Alzheimer's symptoms. In the current study, we aimed to explore …
Some heterocycles connected to substituted piperazine by 1, 3, 4-oxadiazole linker: Design, synthesis, anticholinesterase and antioxidant activity
Z Kilic-Kurt, D Konyar, H Okur, A Kaplan… - Journal of Molecular …, 2025 - Elsevier
AD is a multifactorial neurodegenerative disease that has caused morbidity and mortality on
a global scale. Currently, there are only a few drugs used in the treatment of AD. Although …
a global scale. Currently, there are only a few drugs used in the treatment of AD. Although …
Synthesis of anthraquinone-connected coumarin derivatives via grindstone method and their evaluation of antibacterial, antioxidant, tyrosinase inhibitory activities with …
Anthraquinones and coumarins have excellent pharmacological activities and are an
important class of natural plant metabolites with various biological activities. In this study …
important class of natural plant metabolites with various biological activities. In this study …